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Lumbar Spine Injuries in Recreational Athletes: A Review.
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedic Surgery (Dr. Hsu), Northwestern University Feinberg School of Medicine, Chicago, IL, the Department of Orthopaedic Surgery, Atrium Health (Dr. Turk), Carolinas Medical Center, Charlotte, NC, and the OrthoCarolina Spine Center (Dr. Spector), Charlotte, NC.
Back pain that is associated with lumbar spine pathology is a growing issue in the athlete population. As an aging population continues to remain active, it is essential for primary care physicians, general orthopaedic surgeons, and spine surgeons alike to understand the nuances of diagnosis and management in the recreational athlete population. This is a unique population due to the increased importance placed on returning to high levels of activity, but, by definition, they enjoy less resources and financial incentive to optimize their rehabilitation and return to sport compared with professional athletes.
View Article and Find Full Text PDFProduction of HMF-derivatives from wine residues using Saccharomyces cerevisiae as whole-cell biocatalyst.
Bioresour Bioprocess
January 2025
CEB - Centre of Biological Engineering, University of Minho, Campus Gualtar, Braga, 4710-057, Portugal.
Background: There is an urgent need to develop bioprocesses independent of fossil resources to address resource depletion and mitigate environmental harm. Transitioning to a bio-based economy requires prioritizing chemical production processes that utilize renewable resources, ensuring sustainability and environmental responsibility. 5-Hydroxymethylfurfural (HMF) and its derivatives are promising building blocks, ranked among the top 12 bio-based molecules derived from biomass.
View Article and Find Full Text PDFCost-utility analysis of ropeginterferon alfa-2b to manage low-risk patients with polycythemia vera as compared to phlebotomy only in the Austrian healthcare system.
Ann Hematol
January 2025
FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy.
Treatment of polycythemia vera (PV) aims to maintain hematocrit on target to reduce risk of thrombotic complications, while preventing disease progression to myelofibrosis (MF) and acute myeloid leukemia (AML). This analysis evaluated cost-effectiveness of adding ropeginterferon alfa-2b (ropegIFNα) to phlebotomy in patients with low-risk PV (those younger than 60 years without prior thrombosis), compared to phlebotomy alone. We combined a 12-month decision tree with a semi-Markov cohort model comparing ropegIFNα to the standard treatment from the Austrian healthcare system perspective over 30 years.
View Article and Find Full Text PDFElevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Adv Sci (Weinh)
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Disruption of the intestinal epithelial barrier results in increased permeability and is a key factor in the onset and progression of Crohn's disease (CD). The protein SPARC is primarily involved in cell interaction and migration, but its specific role in the intestinal epithelial barrier remains unclear. This study demonstrates that SPARC is significantly overexpressed in both CD patients and murine models of colitis.
View Article and Find Full Text PDFQuorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24.
Adv Sci (Weinh)
January 2025
Institute of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
The coordination of public and private goods production is essential for bacterial adaptation to environmental changes. Quorum sensing (QS) regulates this balance by mediating the trade-off between the communal benefits of "public goods," such as siderophores and antibiotics, and the individual metabolic needs fulfilled by "private goods," such as intracellular metabolites utilized for growth and survival. Pseudomonas fluorescens 2P24 harbors a LasI/LasR-type QS system, MupI/MupR, which regulates mupirocin production through signaling molecules.
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