Protein serine/threonine phosphatases.

Curr Opin Biotechnol

Agouron Pharmaceuticals Inc., La. Jolla, CA 92037, USA.

Published: August 1996

In the past year, the three-dimensional structures of two serine/threonine phosphatases, protein phosphatase-1 and protein phosphatase-2b (calcineurin), have been determined. The new information puts previous sequence comparisons and mutagenesis studies into a detailed structural perspective. The active-site structure and catalytic mechanism appear to be common to a variety of phosphoesterase enzymes.

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http://dx.doi.org/10.1016/s0958-1669(96)80114-5DOI Listing

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