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Apoptosis-Inducing and Proliferation-Inhibiting Effects of Doramectin on Mz-ChA-1 Human Cholangiocarcinoma Cells.
Int J Mol Sci
December 2024
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Cholangiocarcinoma is a malignant tumor that emerges in the intrahepatic or extrahepatic bile ducts. Doramectin (DOR), a third-generation derivative of avermectins (AVMs), is renowned for its low toxicity and high efficiency. However, no research has hitherto focused on the anti-cholangiocarcinoma effects of these drugs.
View Article and Find Full Text PDFRole of autophagy in resistance to ivermectin in Haemonchus contortus.
Vet Parasitol
January 2025
School of Life Sciences, Ningxia University, Yinchuan 750021, China; Key Lab of Ministry of Education for the Protection and Utilization of Special Biological Resources in Western China, Ningxia University, Yinchuan 750021, China. Electronic address:
Haemonchus contortus is a highly pathogenic gastrointestinal nematode that parasitizes the abomasum of cattle, sheep, and other ruminants. Long-term use of large quantities of ivermectin (IVM) to control H. contortus has resulted in the development of drug resistance.
View Article and Find Full Text PDFRepositioning anthelmintics for the treatment of inflammatory-based pathological conditions.
Inflammopharmacology
November 2024
Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí (UFPI), Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.
Acute, uncontrolled and/or long-lasting inflammation causes a breakdown in immunological tolerance, leading to chronicity and contributing to a series of significant local or systemic tissue changes. Anti-inflammatory efficacy, fewer adverse effects, improved selectivity, and curative action are imminent issues for patients suffering from chronic inflammation-related pathologies. Then, we performed a complete and critical review about anthelmintics, discussing the main classes and the available preclinical evidence on repurposing to treat inflammation-based conditions.
View Article and Find Full Text PDFCrystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1.
Acta Crystallogr F Struct Biol Commun
December 2024
Dartmouth Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Article Synopsis
- Onchocerca volvulus is responsible for serious health issues, including blindness and neurological diseases, and current treatments like ivermectin can't be safely used in pregnant women or those co-infected with Loa loa.
- Researchers at the Seattle Structural Genomics Center for Infectious Disease have successfully produced and crystallized a potential drug target called OvMIF-1, which has a unique jellyfish-like structure.
- The study suggests that deleting its N-terminal tag could reveal a larger cavity for drug targeting, indicating the need for further analysis to confirm the true biological structure of OvMIF-1.
Evaluation of a novel biplex rapid diagnostic test for antibody responses to Loa loa and Onchocerca volvulus infections.
PLoS Negl Trop Dis
October 2024
UMI 233 TransVIHMI, Université Montpellier, Institut de Recherche pour le Développement (IRD), INSERM Unité 1175, Montpellier, France.
Article Synopsis
- Loiasis, caused by the Loa loa worm and affecting around 10 million people in Central Africa, presents challenges in diagnosis and treatment due to potential severe reactions to ivermectin used for other infections.
- Diagnosis typically involves identifying adult worms or microfilariae in blood, but many infections are "occult," prompting the need for new diagnostic tools.
- This study compared two serological rapid antibody tests for loiasis and onchocerciasis, evaluating their effectiveness in diagnosing infections among participants, revealing a high prevalence of both microfilaremia and symptoms related to loiasis.
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