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Benchmarking is an important step in the improvement, assessment, and comparison of the performance of drug discovery platforms and technologies. We revised the existing benchmarking protocols in our Computational Analysis of Novel Drug Opportunities (CANDO) multiscale therapeutic discovery platform to improve utility and performance. We optimized multiple parameters used in drug candidate prediction and assessment with these updated benchmarking protocols.
View Article and Find Full Text PDFApplication of model-informed drug development (MIDD) for dose selection in regulatory submissions for drug approval in Japan.
J Pharmacokinet Pharmacodyn
January 2025
Clinical Pharmacology Development Area, MSD K.K., Tokyo, Japan.
Model-informed drug development (MIDD) is an approach to improve the efficiency of drug development. To promote awareness and application of MIDD in Japan, the Data Science Expert Committee of the Drug Evaluation Committee in the Japan Pharmaceutical Manufacturers Association established a task force, which surveyed MIDD applications for approved products in Japan. This study aimed to reveal the trends and challenges in the use of MIDD by analyzing the survey results.
View Article and Find Full Text PDFProton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, USA.
Objectives: Radiotherapy manages pancreatic cancer in various settings; however, the proximity of gastrointestinal (GI) luminal organs-at-risk (OAR) poses challenges to conventional radiotherapy. Proton beam therapy (PBT) may reduce toxicities compared to photon therapy. This consensus statement summarizes PBT's safe and optimal delivery for pancreatic tumors.
View Article and Find Full Text PDFUse of Supplemental Rod Constructs in Adult Spinal Deformity Surgery: A Review.
Oper Neurosurg (Hagerstown)
January 2025
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA.
Adult spinal deformity comprises a heterogeneous group of disorders that primarily affects older patients and can have a significant negative affect on health-related quality of life. Operative treatment for adult spinal deformity typically entails posterior instrumented fusions that have demonstrated the potential to significantly improve health-related quality of life outcomes. However, until fusion is achieved, the instrumentation providing structural support is subject to repetitive cyclical loading that disproportionately fatigues high-stress areas and can result in instrumentation failure.
View Article and Find Full Text PDFA Comparative Study of Radiation Dose From Chest CT Scan Examinations in Two Imaging Centers in Duhok Province, Kurdistan, Iraq.
Cureus
December 2024
Radiology, Azadi Teaching Hospital, Duhok, IRQ.
Background CT is among the most widely used diagnostic imaging techniques worldwide, providing significant advantages and invaluable diagnostic insights for detecting a wide range of diseases across various organs. However, it involves exposing patients to relatively high levels of ionizing radiation. Objective This study aims to document the radiation doses from chest CT scans performed at Azadi Teaching Hospital in Duhok Province and compare them with those recorded at the 3-Tesla Center for Advanced MRI and CT Scanning, also located in Duhok, using diagnostic reference levels (DRLs) as a benchmark.
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