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Secondary hypersomnia as an initial manifestation of neuromyelitis optica spectrum disorders.
Mult Scler Relat Disord
February 2020
Département de neurologie, Hôpital de la pitié salpêtrière, APHP, Sorbonne Université, Paris 75013, France.
The identification of AQP4-IgG, a specific and pathogenic antibody of NMO/SD has led to a broadening of the clinical spectrum of manifestations of NMO/SD including the presence of encephalic symptoms. Lesions are often distributed on peri‑ependymal area and sometimes affected the diencephalon leading to sleep disorders. We report a case of hypersomnia with polysomnographic documentation during the first attack of NMO/SD.
View Article and Find Full Text PDFAntidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients.
Neuro Endocrinol Lett
April 2016
Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
Objectives: Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. Antidepressants are also frequently administrated in an attempt to suppress cataplexy. We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients.
View Article and Find Full Text PDFLucid dreaming in narcolepsy.
Sleep
March 2015
Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
Objective: To evaluate the frequency, determinants and sleep characteristics of lucid dreaming in narcolepsy.
Settings: University hospital sleep disorder unit.
Design: Case-control study.
Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control study.
Brain Behav Immun
March 2014
Inserm, U1061, F-34000 Montpellier, France; Laboratoire de Biochimie, F-34000 CHRU Montpellier, France; Pôle Gérontologie CHU Montpellier, M2H Euromov, Université Montpellier 1, France.
Recent advances in the identification of susceptibility genes and environmental exposures provide strong support that narcolepsy-cataplexy is an immune-mediated disease. Only few serum cytokine studies with controversial results were performed in narcolepsy and none in the cerebrospinal fluid. We measured a panel of 12 cytokines by a proteomic approach in the serum of 35 patients with narcolepsy-cataplexy compared to 156 healthy controls, and in the cerebrospinal fluid of 34 patients with narcolepsy-cataplexy compared to 17 non-narcoleptic patients; and analyzed the effect of age, duration and severity of disease on the cytokine levels.
View Article and Find Full Text PDF[Value of cerebral spinal fluid measurement of hypocretin-1 in the diagnosis of Chinese patients with narcolepsy].
Zhonghua Yi Xue Za Zhi
July 2013
Department of Respiratory Medicine, People's Hospital, Peking University, Beijing 100044, China.
Objective: To evaluate the diagnostic value of cerebral spinal fluid (CSF) measurement of hypocretin-1 (hcrt-1) in Chinese patients with narcolepsy.
Methods: A total of 139 narcoleptic patients, including 111 narcolepsy with typical cataplexy (NC) and 28 narcolepsy without cataplexy (NWC), were diagnosed at the sleep centre of Peking University People's Hospital from April 2003 to March 2012. And 64 non-narcoleptic controls were recruited.
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