The authors used a disposable original system to recover total blood during surgery and realized 17 transfusions of autologous blood in sheep. No biological or clinical disturbance was observed.
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Cord blood for autologous transfusion in infants with congenital anomalies: Volumes, sterility, and stability during storage.
Transfusion
January 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background: Neonates with congenital anomalies frequently require perioperative allogeneic red blood cell (RBC) transfusion. Whole cord blood for autologous transfusion to neonates may provide an alternative RBC source, but whether sufficient volumes can be collected after delayed cord clamping to reduce allogeneic RBC requirements is unknown.
Study Design And Methods: Inclusion criteria were mothers delivering a viable infant >34 weeks' gestation.
Cell Salvage Using the Autotransfusion Device CATSmart: A Randomized Controlled Bicentric Trial Evaluating the Quality of Two New Flex Wash Programs.
Transfus Med Hemother
December 2024
Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Background: The use of cell salvage and autologous blood transfusion is an important and widespread method of blood conservation during surgeries with expected high blood loss. The continuous autotransfusion device CATSmart (Fresenius Kabi, Germany) contains two new washing programs on the device called Flex wash 3 and Flex wash 5. To the best of our knowledge, there are no published clinical data regarding the performance of the two new washing programs.
View Article and Find Full Text PDFCompact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Effect of cardiopulmonary resuscitation on perfusion in a porcine model of severe hemorrhagic shock.
J Trauma Acute Care Surg
October 2024
From the Department of Surgery (P.G., A.S., D.D., P.D.), Louisiana State University Health Science Center, New Orleans, LA; Department of Surgery (A.C.), University of Tennessee Graduate School of Medicine, Knoxville, TN; Department of Molecular Pharmacology and Physiology (T.S.), University of South Florida, Tampa, FL; School of Medicine (O.W., J.D., A.S.), Louisiana State University Health Science Center, New Orleans, LA; Tulane University School of Medicine (M.C.G., T.C.B.), New Orleans, LA; and Department of Emergency Medicine (K.V.), Louisiana State University Health Science Center, New Orleans, LA.
Article Synopsis
- The study investigated the impact of cardiopulmonary resuscitation (CPR) on brain and skin oxygen levels in pigs experiencing severe hemorrhagic shock, a condition where blood pressure drops critically.
- Using a controlled experiment with 12 swine, results indicated that while CPR increased systolic blood pressure, it did not improve overall tissue oxygenation and, in fact, reduced skin perfusion significantly.
- The findings support previous research suggesting that CPR may not benefit organ oxygenation during hemorrhagic shock and could even have harmful effects.
An evaluation of exagamglogene autotemcel for the treatment of sickle cell disease and transfusion-dependent beta-thalassaemia.
Expert Opin Biol Ther
September 2024
Department of Hematology/Oncology, Children's University Hospital, Tübingen, Germany.
Introduction: Sickle cell disease is the most common hereditary hemoglobinopathy followed by beta-thalassemia. Until recently, allogeneic stem cell transplantation was the only curative approach. Based on the Crispr-Cas9-technology enabling targeting specific genes of interest, fetal hemoglobin which is normally shut-off after birth can be switched on and sufficient levels can alleviate symptoms in sickle cell disease and avoid transfusions in beta-thalassemia.
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