In summary, two large families were subjected to genetic analysis of the distribution of the immune response. S linkage analysis indicated that this locus for positive skin test reaction to antigen E and/or personal history or seasonal allergy is linked to HLA-B. The maximum likelihood estimate of the recombination frequency is 0.13 in males and 0.53 in females, with a lod score of 2.53.
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Ragweed subpollen particles of respirable size activate human dendritic cells.
PLoS One
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Coll Antropol
December 2011
University of Zagreb, "Sestre milosrdnice" University Hospital Center, Children's Hospital Zagreb, Department of Pulmonology, Allergology and Clinical Immunology, Zagreb, Croatia.
Allergic asthma is a multifactorial disease involving well known environmental factors and less identified genetic components. In several studies the HLA genes have been implicated in the development of asthma and atopy, but the importance of these associations remains unclear. The aim of the present study was to analyse the distribution of specificities at HLA class I loci (-A and -B) and HLA class II locus (-DRB1) in a group of 143 Croatian children with atopic asthma, regarding total serum IgE and specific IgE against common inhalant allergens, as well as their connection with different asthmatic phenotypes and to identify HLA genotype which increases the risk for atopy or asthma or which has a protective effect.
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Division of Pulmonary and Critical Care Medicine, Mount Sinai School of Medicine, New York, NY, USA.
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