The Xenopus laevis homologue of the 64-kDa subunit of cleavage stimulation factor.

Comp Biochem Physiol B Biochem Mol Biol

Department of Genetics, Trinity College, Dublin 2, Ireland.

Published: July 1996

Cleavage stimulation factor (CstF) is composed of three subunits of 50, 64 and 77 kDa, respectively. We report here the identification of a cDNA clone from Xenopus laevis encoding a homologue of the 64-kDa subunit of human CstF. Comparative sequence analysis reveals that these two proteins are highly conserved with the exception of a unique repeat structure found in the human, but not in the X. laevis, protein. Analysis of expression of this mRNA during X. laevis tadpole development indicates a requirement for this protein throughout all stages of development.

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http://dx.doi.org/10.1016/0305-0491(96)00023-5DOI Listing

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