Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
The clinical characterisation of polycystic ovary syndrome (PCOS) and its fenotype complicate the search for its genetic causes. Still now, there is no concordance about the exact clinical phenotype for PCOS and there is still an open question whether polycystic ovaries are the necessary part of PCOS at all. Therefore, the author suggests to accept and follow Legro's proposal and genetic models in the future investigations of PCOS. Through the ethnic, familial cluster studies, through molecular genetic examinations and novel technology, we may be able to solve the problem of PCOS and find it out, how much the PCOS could be connected with mutations in human genome and how much could be the importance of environmental factors in PCOS.
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