Objectives: To determine if the sera of patients with acute promyelocytic leukemia (APL) and all-trans retinoic acid (ATRA) inhibit the formation of colony-forming-unit of megakaryocyte (CFU-Meg).
Methods: By cellular culture assay, the sera of 22 APL patients treated with ATRA and 10(-6)' mol/L ATRA were kinetically used to perform the investigation. Meanwhile, serum tumor necrosis factor (TNF) activity and bone marrow CFU-L were also detected.
Results: Before treatment, there was an inhibitory activity on CFU-Meg in the serum of APL patients (29.6% +/- 2.4%). The activity reduced gradually with the treatment and was stimulus when bone marrow remission obtained (-18.7% +/- 4.1%, P < 0.001). It was positively correlated with TNF activity in the serum and the number of CFU-L however negatively correlated with the number of megakaryocyte in bone marrow and PLT. Serum TNF activity and the number of CFU-L before treatment were higher than those after treatment (P < 0.05 and < 0.001, respectively). ATRA could stimulate the growth of CFU-Meg.
Conclusions: There was an inhibitory activity in the serum of APL patients which could be used to monitor the efficacy of the therapy. ATRA stimulates the growth of CFU-Meg.
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