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Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21.
BBA Adv
December 2024
Genos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Down syndrome (DS), a genetic condition caused by trisomy 21 (T21), manifests various neurological symptoms, including intellectual disability, early neurodegeneration, and early-onset dementia. N-glycosylation is a protein modification that plays a critical role in numerous neurobiological processes and whose dysregulation is associated with a range of neurological disorders. However, whether N-glycosylation of neural glycoproteins is affected in DS has not been studied.
View Article and Find Full Text PDFPalmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.
Eur J Med Res
January 2025
Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
Background: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.
Methods: This study retrieved AD data sets from the GEO database to identify palmitoylation-associated genes (PRGs). This study applied WGCNA along with three machine learning algorithms-random forest, LASSO regression, and SVM-RFE-to further select key PRGs (KPRGs).
Metacognition in the listening brain.
Trends Neurosci
January 2025
Department of Psychology, University of Lübeck, 23562 Lübeck, Germany; Center of Brain, Behavior, and Metabolism, University of Lübeck, 23562 Lübeck, Germany. Electronic address:
How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearing and communication is only beginning to be explored, and the neuroscience behind it is an emerging field: how does confidence express in neural dynamics of the listening brain? What is known about auditory metaperceptual alterations as a hallmark phenomenon in psychosis, dementia, or hearing loss? Building on Bayesian ideas of auditory perception and auditory neuroscience, 'meta-listening' offers a framework for more comprehensive research into how metacognition in humans and non-humans shapes the listening brain.
View Article and Find Full Text PDFNuclear podosomes regulates cellular migration in Tau and Alzheimer's disease.
Adv Protein Chem Struct Biol
January 2025
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences Hospital (NIMHANS), Institute of National Importance, Bangalore, Karnataka, India. Electronic address:
The neuronal cytoskeleton has remained a less explored area of research in establishing neuroprotection. HDAC6 has been studied with respect to many neurodegenerative diseases, especially AD. It exhibits the ability to interact with various cytoskeletal proteins and to promote migration in cells.
View Article and Find Full Text PDFLipid role in synapse and nuclear envelope-associated endocytic pathways in Tauopathy.
Adv Protein Chem Struct Biol
January 2025
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences Hospital (NIMHANS), Institute of National Importance, Bangalore, Karnataka, India.
Lipids play an essential role in synaptic function, significantly impacting synaptic physiology through their dynamic nature and signaling capabilities. Membrane lipids, including cholesterol, phospholipids, and gangliosides, are crucial for synaptic organization and function. They act as structural integrators and signaling molecules, guiding vesicle intracellular movement and regulating enzyme activity to support neuronal activity.
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