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Diversity and Evolution of the Mobilome Associated with Antibiotic Resistance Genes in .
Microb Drug Resist
January 2025
NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
is an important cause of pyogenic infections, bacteremia, and chronic maxillary sinusitis. Mobile genetic elements (MGEs) play a key role in lateral gene transfer, resulting in broad transfer of antibiotic resistance genes (ARGs). However, studies on ARG-associated MGEs in are still rare.
View Article and Find Full Text PDFPeritonitis-related bacterial infections: a large-scale case-series retrospective study in 160 domestic animals (2009-2022).
Braz J Microbiol
December 2024
Department of Animal Production and Preventive Veterinary Medicine, Faculty of Veterinary Medicine and Animal Sciences- FMVZ, Infectious Diseases of Domestic Animals, Sao Paulo State University - UNESP, Botucatu, SP, 18618-681, Brazil.
Bacterial peritonitis infections comprise a life-threatening clinical condition in domestic animals that commonly lead to sepsis and high mortality. A set of bacterial pathogens have been identified in septic peritonitis in livestock and companion animals. Nonetheless, most descriptions are restricted to case reports or limited to only one domestic species, and a restrict number of comprehensive studies involving this infection has focused on a great number of domestic animals.
View Article and Find Full Text PDFMolecular dissection of the chromosome partitioning protein RocS and regulation by phosphorylation.
J Bacteriol
October 2024
Molecular Microbiology and Structural Biochemistry, Université de Lyon, CNRS, Lyon, France.
Chromosome segregation in bacteria is a critical process ensuring that each daughter cell receives an accurate copy of the genetic material during cell division. Active segregation factors, such as the ParABS system or SMC complexes, are usually essential for this process, but they are surprisingly dispensable in . Rather, chromosome segregation in relies on the protein Regulator of Chromosome Segregation (RocS), although the molecular mechanisms involved remain elusive.
View Article and Find Full Text PDFA nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.
World J Microbiol Biotechnol
September 2024
Laboratory of Molecular Microbiology and Biotechnology (LAMMB), Department of Medical Biotechnologies, University of SienaViale Bracci, Policlinico Le Scotte, V Lotto I Piano, 53100, Siena, Italy.
The present work reports the development and validation of a chromosomal expression system in Streptococcus pneumoniae which permits gene expression under the control of Lactococcus lactis lantibiotic nisin. The system is based on the integrative and conjugative element (ICE) Tn5253 of S. pneumoniae capable of site-specific chromosomal integration and conjugal transfer to a variety of bacterial species.
View Article and Find Full Text PDFUnveiling the regulatory network controlling natural transformation in lactococci.
PLoS Genet
July 2024
Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Lactococcus lactis is a lactic acid bacterium of major importance for food fermentation and biotechnological applications. The ability to manipulate its genome quickly and easily through competence for DNA transformation would accelerate its general use as a platform for a variety of applications. Natural transformation in this species requires the activation of the master regulator ComX.
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