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An Advanced Multivalent Ligand-Decorated Microsphere Enrichment System Efficiently Captures Circulating Tumor Cells In Vivo.
Small
January 2025
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Capturing circulating tumor cells (CTCs) in vivo from the bloodstream lessens tumor metastasis and recurrence risks. However, the absence of CTC receptors due to epithelial-mesenchymal transition (EMT), the limited binding capacity of a single ligand, and the complexity of the blood flow environment significantly reduce the efficiency of CTC capture in vivo. Herein, a multivalent ligand-decorated microsphere enrichment system (MLMES) is crafted that incorporates a capture column replete with an immunosorbent that precisely recognizes and binds the stably expressed cluster of differentiation 44 (CD44) and glucose transporter protein 1 (GLUT1) receptors present on the exterior of CTCs.
View Article and Find Full Text PDFNon-Cell-Based Extracorporeal Artificial Liver Systems: Historic Perspectives, Approaches and Mechanisms, Current Applications, and Challenges.
Artif Organs
December 2024
Department of Mechanical Engineering, University of Washington, Seattle, Washington, USA.
Background: Liver disease is a growing burden. Transplant organs are scarce. Extracorporeal liver support systems (ELSS) are a bridge to transplantation for eligible patients.
View Article and Find Full Text PDFPolymyxin B Hemoperfusion in Sepsis: A Possible Silver Lining to the Dark Clouds?
Indian J Crit Care Med
October 2024
Department of Critical Care, Artemis Health Institute, Gurgaon, Haryana, India.
Sharma J, Khatav SK. Polymyxin B Hemoperfusion in Sepsis: A Possible Silver Lining to the Dark Clouds? Indian J Crit Care Med 2024;28(10):903-905.
View Article and Find Full Text PDF[Extracorporeal treatment in poisoning].
Med Klin Intensivmed Notfmed
September 2024
Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 27, 8036, Graz, Österreich.
Article Synopsis
- In rare cases, patients who are intoxicated may need extracorporeal procedures to help remove toxins from their bodies more effectively.
- The EXTRIP workgroup provides updated guidelines based on evidence and consensus for using these procedures in critically ill, poisoned patients.
- The best results for toxin removal occur with substances that have specific properties, and intermittent hemodialysis is the most effective method, while continuous procedures are better for patients with compromised blood flow.
Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup.
Nephrol Dial Transplant
November 2024
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany; and Outcomes Research Consortium, Cleveland, OH, USA.
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possible to deliver more biocompatible extracorporeal adsorption therapies to patients with a variety of conditions. There are several key rationales based on physicochemical principles and clinical considerations that justify the application and investigation of such therapies as evidenced by multiple ex vivo, experimental and clinical observations.
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