HIV infection in connection with other venereal diseases change greatly there clinic development. Authors discuss comprehensively the peculiarities of infectious process in case of syphilis connection with HIV-infection, and in particular face syphilid, which is met little in practice of venereologists. Syndrome of aggravating influence of HIV-infection on clinic syphilis development is noted. It usually more serious. In given example syphilis was diagnosed only two month later after patient had took medical advice.

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