Objective: To perform color image analysis to assess the course of morphometric and proliferative changes in the intima and media of rabbit carotid arteries following balloon injury.
Study Design: Proliferating smooth muscle cells were labeled with proliferating cell nuclear antigen and vizualized by immunohistochemical staining of histologic sections. Morphometry was performed on histologic cross-sections of injured arteries stained with hematoxylin.
Results: The development of intimal hyperplasia following an acute mechanical injury was detectable early on and was accompanied by a burst of cell proliferation. Medial cell proliferation peaked on day 3 after balloon injury, and the maximum of intimal cell proliferation was noted on day 7.
Conclusion: The color image analysis method described here could be a useful tool in evaluating drugs for their ability to prevent restenosis.
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