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Zero-dose children and the extended immunisation cascade: Understanding the path to full immunisation with six childhood vaccines in 43 countries.
J Glob Health
September 2024
International Center for Equity in Health, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Article Synopsis
- - The World Health Organization aims to cut in half the number of children who receive no routine vaccinations by 2030, focusing on both newer vaccines like PCV and ROTA, as well as traditional ones like BCG and DPT.
- - An analysis of data from 43 low- and middle-income countries revealed that 9% of children received no vaccines, while 58.6% received at least one dose, and 47.2% were fully vaccinated with all recommended doses.
- - Prioritizing children who haven't received any vaccines is critical, as getting them their first vaccination increases the likelihood of them completing their immunisation schedule, supporting efforts to achieve global health goals.
Neonatal BCG Vaccination for Prevention of Allergy in Infants: The MIS BAIR Randomised Controlled Trial.
Clin Exp Allergy
September 2024
Infectious Diseases, Clinical Epidemiology & Biostatistics Unit, Population Allergy, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Background: The beneficial off-target effects of Bacille Calmette-Guérin (BCG) vaccination potentially include protection against allergy.
Objective: In the MIS BAIR trial, we aimed to determine whether neonatal BCG vaccination reduces atopic sensitisation and clinical food allergy in infants.
Methods: In this randomised controlled trial, 1272 neonates were allocated to BCG-Denmark vaccine (0.
Background: The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date. In this study, our aim was to reveal the profiles of antibody responses induced by BCG vaccination in adults and identify the potential biomarkers for evaluating the BCG vaccination response.
Methods: Proteome microarrays were performed to reveal the serum profiles of antibody responses induced by BCG vaccination in adults.
An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis.
Vaccine
September 2024
Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77054, USA. Electronic address:
Mucosal vaccines have the potential to elicit protective immune responses at the point of entry of respiratory pathogens, thus preventing even the initial seed infection. Unlike licensed injectable vaccines, mucosal vaccines comprising protein subunits are only in development. One of the primary challenges associated with mucosal vaccines has been identifying and characterizing safe yet effective mucosal adjuvants that can effectively prime multi-factorial mucosal immunity.
View Article and Find Full Text PDFCase Report: Clinical and Pathological Findings of Tuberculous Gumma: A Case Report and Literature Review.
Am J Trop Med Hyg
April 2024
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tuberculous gumma (TG) is a rare type of cutaneous tuberculosis thought to occur as a result of the hematogenous spread of Mycobacterium tuberculosis, which is more common in immunosuppressed individuals. An 8-year-old boy presented with a 2-month history of multiple indolent enlarging ulcerated nodules on his left upper extremity. He had a past medical history of bacille Calmette-Guerin vaccine induced lupus vulgaris.
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