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Novel Peptidomimetic Cyclo-{E(I)-E(W)}Na (CP-88) with Hematopoietic Activity Sustained in Invasive and Oral Administration: Experimental and Preclinical Evaluation.
Int J Mol Sci
December 2024
Institute of Experimental Medicine, Acad. Pavlov Street, 12, 197022 St. Petersburg, Russia.
Over the last decades, significant progress has been made in studying agonistic and antagonistic hematopoietic peptides. The main disadvantage of this class of peptides is their low stability with noninvasive administration methods, which limits the widespread use of hematopoiesis-regulated peptide drugs in medical practice. The aim of this work is to study novel peptidomimetics with hematopoietic activity sustained in invasive and oral administration.
View Article and Find Full Text PDFMelatonin Receptors and Serotonin: Age-Related Changes in the Ovaries.
J Pers Med
September 2024
Department of Urology, Medical Institute, St. Petersburg University, Mendeleevskaya Line 2, 197036 St. Petersburg, Russia.
Introduction: Melatonin and serotonin can influence certain aging processes in the ovaries. The main melatonin receptors are represented by types MT1 and MT2. The goal of investigation.
View Article and Find Full Text PDFMolecular mechanisms of the anticancer action of fustin isolated from Scop. in MDA-MB-231 triple-negative breast cancer cell line.
Z Naturforsch C J Biosci
September 2024
Department of Pharmacology and Clinical Pharmacology and Therapeutics, Faculty of Medicine, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria.
The aim of the present work was to investigate some of the molecular mechanisms and targets of the anticancer action of the bioflavonoid fustin isolated from the heartwood of Scop. in the triple-negative breast cancer cell line MDA-MB-231. For this purpose, we applied fluorescence microscopy analysis to evaluate apoptosis, necrosis, and mitochondrial integrity, wound healing assay to study fustin antimigratory potential and quantitative reverse transcription-polymerase chain reaction to analyze the expression of genes associated with cell cycle control, programmed cell death, metastasis, and epigenetic alterations.
View Article and Find Full Text PDFFirst Insight into the Prevalence of Infection among Veterinary Medicine Students in Bulgaria.
Infect Dis Rep
August 2024
French Reference Center for Rickettsioses, Q Fever and Bartonelloses, IHU-Méditerranée Infection, 13005 Marseille, France.
Article Synopsis
- * Overall, 29.7% of students tested positive for infection markers, with Stara Zagora students showing higher rates (33.6%) compared to Sofia students (23%).
- * Higher seropositivity was found in male students (32.8%) compared to females (16.0%), highlighting the need for improved safety protocols and infection control in veterinary training programs.
Time-Dependent Shifts in Intestinal Bacteriome, Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation.
Biomedicines
July 2024
R. Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov First State Medical University of St. Petersburg, L. Tolstoy St, 6-8, 197022 St. Petersburg, Russia.
Article Synopsis
- Dose-intensive therapies during allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly disrupt gut microbiota and promote antibiotic resistance, with recovery patterns poorly understood.
- In a study of 12 adult patients, stool samples revealed a marked decline in microbial diversity starting from day 0, persisting for up to a year, with specific bacterial genera showing slower recovery.
- A rise in antibiotic-resistant bacteria was observed around day 30 post-transplant, with resistance to major antibiotic classes, but a gradual decrease in resistance levels was noted over the following year.
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