Growth associated protein 43 (GAP43) mRNA was found in scattered groups of chromaffin cells prenatally, and in chromaffin noradrenaline cells from postnatal day 6 (P6). The distinct adult distribution of GAP43 mRNA in chromaffin cells appeared between P10 and P16. High levels of GAP43 mRNA were found in intra-adrenal ganglion neurons also expressing neuropeptide tyrosine (NPY) mRNA (type I ganglion neurons), and at prenatal and early postnatal stages in large medullarly clusters of NPY mRNA containing cells, probably representing type I ganglion neurons precursors. The expression of GAP43 mRNA in noradrenaline-producing chromaffin cells and type I ganglion neurons suggests an important role for GAP43 in these cells both during development and in adult life.
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