We compared the pattern reversal visual evoked response (PVER) amplitude-check size functions from 25 eyes (25 normal subjects; visual acuities > or = 20/20) with those from 32 eyes (22 patients; visual acuities 20/15 to 20/50; mean, 20/25.5) with mild optic nerve disease to determine if spatial tuning loss of the PVER occurs in the presence of optic nerve dysfunction. The steady-state PVER was recorded with five check sizes (range, 160 to 10 minutes of arc). To analyze the PVER amplitude-check size function, we calculated the difference between the maximum and minimum PVER amplitudes and then calculated the area of spatial tuning (the area under the function). Values were significantly smaller in patients than in normal subjects (1.81 +/- 1.27 microV versus 5.73 +/- 3.27 microV; F = 41.24, p = 0.0001; 3.87 +/- 2.70 area units versus 12.57 +/- 7.60 area units; F = 38.62, p = 0.0001). There was no shift in the distribution of peak check sizes. Results suggest that a spatial tuning loss occurs in optic nerve disease. The shape of the function, including the area of spatial tuning, appears to be a sensitive indicator of early or mild optic nerve dysfunction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0420.1996.tb00065.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disentangling Driving Force Effects, Polar Effects, /H Imbalance, and Other Influences on H-Atom Transfer Reactions.
J Am Chem Soc
January 2025
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.
Hydrogen atom transfer (HAT) reactions and their kinetic barriers Δ are important in organic and inorganic chemistry. This study examines factors that influence Δ, reporting the kinetics and thermodynamics of HAT from various ruthenium bis(acetylacetonate) pyridine-imidazole complexes to nitroxyl radicals. Across these 36 reactions, the Δ and Δ can be independently varied, with different sets of Ru complexes primarily tuning either their ps or their °s.
View Article and Find Full Text PDFGlobal remapping emerges as the mechanism for renewal of context-dependent behavior in a reinforcement learning model.
Front Comput Neurosci
January 2025
Institute for Neural Computation, Faculty of Computer Science, Ruhr University Bochum, Bochum, Germany.
Introduction: The hippocampal formation exhibits complex and context-dependent activity patterns and dynamics, e.g., place cell activity during spatial navigation in rodents or remapping of place fields when the animal switches between contexts.
View Article and Find Full Text PDFSurface immobilization of single atoms on heteroatom-doped carbon nanospheres through phenolic-mediated interfacial anchoring for highly efficient biocatalysis.
Chem Sci
January 2025
BMI Center for Biomass Materials and Nanointerfaces, National Engineering Laboratory for Clean Technology of Leather Manufacture, Ministry of Education Key Laboratory of Leather Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University Chengdu Sichuan 610065 China
Single-atom catalysts (SACs) dispersed on support materials exhibit exceptional catalytic properties that can be fine-tuned through interactions between the single atoms and the support. However, selectively controlling the spatial location of single metal atoms while simultaneously harmonizing their coordination environment remains a significant challenge. Here, we present a phenolic-mediated interfacial anchoring (PIA) strategy to prepare SACs with Fe single atoms anchored on the surface of heteroatom-doped carbon nanospheres.
View Article and Find Full Text PDFFeature-selective adaptation of numerosity perception.
Proc Biol Sci
January 2025
Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, Florence, Italy.
Perceptual adaptation has been widely used to infer the existence of numerosity detectors, enabling animals to quickly estimate the number of objects in a scene. Here, we investigated, in humans, whether numerosity adaptation is influenced by stimulus feature changes as previous research suggested that adaptation is reduced when the colour of adapting and test stimuli did not match. We tested whether such adaptation reduction is due to unspecific novelty effects or changes of stimuli identity.
View Article and Find Full Text PDFThe flat-top beams have significant potential for applications in micromachining and biomedicine, due to their unique intensity distribution. Therefore, spatiotemporal flat-top beams, which are all flat-top in both spatial and time domains, may significantly advance its development. Here, we demonstrate the generation of a spatiotemporal flat-top beam using an all-fiber mode-locked laser.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!