Objective: To study the influence of moderate physical activity on serum concentrations of digoxin, digitoxin and albumin.
Methods: Blood samples were drawn from 10 consecutive mobile patients on digoxin and 12 patients on digitoxin therapy before and following a 10-min walking period. Digitalis serum concentrations were determined by radioimmunoassay, and albumin serum concentrations by laser nephelometry.
Results: Following physical activity, digoxin serum concentrations dropped immediately to 79% of baseline values and remained significantly decreased for 20 min. Digitoxin concentrations did not change significantly.
Conclusion: In contrast to digoxin, the effect of physical activity the serum concentration of digitoxin can be disregarded.
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