High or pharyngo-oesophageal dysphagia (PD) is defined as difficulty in initiating the act of swallowing within 1s. It involves the mechanisms controlling the tongue, pharynx and upper oesophageal sphincter (UOS) and is associated with a wide variety of local, neurologic and muscular disorders, and can also occur after surgery in the area and in response to gastro-oesophageal reflux (GOR). Our study aims at defining the criteria for surgery in PD and to evaluate the clinical results of such treatment. Twenty-three patients who underwent surgery were evaluated with pharyngo-oesophageal motility and ambulatory 24-hr pH-metry. The following parameters were measured: 1) pharyngeal contraction amplitude, 2) duration, 3) repetitive pharyngeal contractions, 4) UOS tone, 5) percentage of UOS relaxation, 6) duration of relaxation, 7) UOS closing pressure, 8) UOS closing duration, 9) co-ordination of UOS closing pressure and upper oesophageal (UO) contractions. Preoperative manometry showed a variety of abnormalities in several of the parameters, such as prolonged pharyngeal contraction ("spasm"), unco-ordinated pharyngeal contractions and UOS relaxation, low amplitude pharyngeal contractions, unco-ordinated UOS closing tone and UO contractions and hypotonic UO. Surgery was directed at the specific abnormality in each patient taking into consideration the presence or absence of GOR. Seventeen patients (74%) had excellent results. Three other patients (13%), who had improved swallowing but who continued to have GOR complicated by some oesophageal dysmotility, oesophagitis and an oesophageal web, underwent subsequent anti-reflux surgery with relief of symptoms. In conclusion, pharyngo-oesophageal motility measurement is mandatory in PD, especially when a diverticulum is absent. Cricopharyngeal myotomy with or without diverticulectomy as indicated produces excellent results. Associated oesophageal problems have to be dealt with appropriately.
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Trop Med Infect Dis
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Evolutionary Ecology Group, Department of Biology, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, 2610 Antwerp, Belgium.
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December 2024
Department of Environmental Horticulture, University of Seoul, Seoul, Republic of Korea. Electronic address:
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View Article and Find Full Text PDFFoods
November 2024
Faculty of Technology, University of Niš, Bulevar Oslobodjenja 124, 16000 Leskovac, Serbia.
This study aims to assess the capability of using a specially designed device to monitor changes in gas concentration (CO, NH, HS, and O) in the atmosphere above the minced beef meat, during storage at refrigerated temperature. With its array of sensing channels, the multi-gas detector device facilitates the detection of precise gas concentrations in sensitive environments, enabling the monitoring of various processes occurring within stored meat. To delve into the connection between microbial activity and gas emissions during storage, fluctuations in microbial populations in the meat were observed, focusing on prevalent meat microbiota such as lactic acid bacteria (LAB) and .
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Department of Women's and Children's Health, Salesi Hospital, Ancona, 60123, Italy.
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Sci Rep
September 2024
Department of Electrical and Computer Engineering and Center for Quantum Information Processing, University of Seoul, 163 Seoulsiripdae-Ro, Dongdaemun-Gu, Seoul, 02504, Republic of Korea.
Unification of gravity with quantum mechanics is still a terra incognita. Photon polarization measurements offer a unique window for probing the interaction between these two fundamental forces. We have revealed that non-reciprocity in the photon polarization angle can arise by tailoring the quantization axis, which corresponds to the direction of polarizer.
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