Islet cell tumors are a relatively rare group of neuroendocrine tumors that are often difficult to image preoperatively. We present the magnetic resonance imaging characteristics of an uncommon and unusually large extrapancreatic gastrinoma.
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Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
JAMA Surg
March 2018
Digestive Diseases Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland
Article Synopsis
- Zollinger-Ellison syndrome (ZES) is a serious condition caused by gastrin-secreting tumors (gastrinomas), primarily found in the pancreas or duodenum, whereas this study examines rare gastrinomas located in the liver and bile ducts.
- Conducted at the National Institutes of Health and Stanford University Hospital with 223 patients involved, this research highlights the incidence, surgical results, and survival rates associated with these unusual tumors over a 35-year period.
- Among the patients, only 7 had liver or biliary gastrinomas, with varying surgical procedures performed; most patients had complications but no operative deaths, and all patients showed positive results for gastrin levels and secretin tests.
[Surgery for gastrinoma: Short and long-term results].
Cir Esp
June 2017
Departamento de Cirugía, Universidad de Barcelona, Hospital Clínic de Barcelona, Barcelona, España.
Introduction: Zollinger-Ellison syndrome (Z-E) is characterized by gastrin-secreting tumors, responsible for causing refractory and recurrent peptic ulcers in the gastrointestinal tract. The optimal approach and the extension of tumor resection remains the subject of debate.
Methods: During the period February 2005 and February 2014, 6 patients with Z-E underwent surgery, 4 men and 2 women with a median age 46.
A tale of two tumors: treating pancreatic and extrapancreatic neuroendocrine tumors.
Annu Rev Med
September 2015
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030; email: ,
Despite their perceived rarity, gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rising in incidence and prevalence. The biology, natural history, and therapeutic options for GEP-NETs are heterogeneous: NETs arising in the pancreas can be distinguished from those arising elsewhere in the gastrointestinal tract, and therapy is dichotomized between these two groups. Somatostatin analogues are the mainstay of oncologic management of bowel NETs; everolimus, streptozocin, and sunitinib are approved to treat pancreatic NETs.
View Article and Find Full Text PDF[PPI-sensitive diarrhea - unusual case of an adolescent with sporadic gastrinoma].
Dtsch Med Wochenschr
September 2012
Medizinische Klinik, Israelitisches Krankenhaus, Hamburg.
History And Clinical Findings: A 14-year-old boy was admitted to hospital because of chronic episodic diarrhea lasting for 4 years. Previous investigations in the past had not revealed the cause of the symptoms.
Investigations: The 13C-triglyceride breathing test showed a diminished intestinal lipolysis.
Zollinger-Ellison syndrome associated with a history of alcohol abuse: coincidence or consequence?
Surgery
December 2011
Division of Surgical Oncology, Department of Surgery, Froedtert Hospital/Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Background: This 47-year observational study suggests that sporadic Zollinger-Ellison (Z-E) syndrome, particularly duodenal wall gastrinomas (DWG), is associated with a history of alcohol abuse.
Methods: Thirty-nine consecutive Z-E patients were followed from 1962 through 2010. The drinking patterns of these patients were assessed and compared with 3,786 community controls.
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