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A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-associated hepatitis.
Hepatol Commun
August 2024
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- Alcohol-associated hepatitis (AH) has a high mortality rate and challenges in identifying patients at risk, prompting research into the extracellular matrix as a potential predictor for mortality.
- Plasma samples from 62 AH patients revealed over 1600 peptide features linked to significant proteins, with notable changes corresponding to disease severity and associated with specific proteases.
- Three peptides showed strong links to 90-day mortality, leading to a promising noninvasive method for predicting outcomes in AH patients that could enhance current prognostic tools.
Predictive Validity of Multifactorial Injury Risk Models and Associated Clinical Measures in the U.S. Population.
Sports (Basel)
April 2024
Department of Athletic Training, College of Health Professions and Human Services, Kean University, 1000 Morris Avenue, Union, NJ 07083, USA.
Popular movement-based injury risk screens were shown to lack predictive precision, leading to interest in multifactorial models. Furthermore, there is a lack of research regarding injury risk assessment for those currently or planning to be recreationally active. This study aims to provide injury risk insights by analyzing multifactorial injury risk models and associated clinical measures in the U.
View Article and Find Full Text PDFUnlabelled: Alcohol-related hepatitis (AH) is plagued with high mortality and difficulty in identifying at-risk patients. The extracellular matrix undergoes significant remodeling during inflammatory liver injury that can be detected in biological fluids and potentially used for mortality prediction. EDTA plasma samples were collected from AH patients (n= 62); Model for End-Stage Liver Disease (MELD) score defined AH severity as moderate (12-20; n=28) and severe (>20; n=34).
View Article and Find Full Text PDFAlbumin and fibrinogen synthesis rates in advanced chronic liver disease.
Am J Physiol Gastrointest Liver Physiol
November 2023
Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
Synthesis of plasma proteins is an important function of the liver that has sparsely been investigated by modern techniques in patients with advanced chronic liver disease (CLD). Twenty-eight well-characterized patients with CLD under evaluation for liver transplantation were included. Albumin and fibrinogen synthesis rates were measured by the flooding dose technique using stable isotope-labeled phenylalanine.
View Article and Find Full Text PDFMyocardial injury after non-cardiac surgery and per operative fibrin metabolism in patients undergoing hip-fracture surgery: an observational study.
Scand J Clin Lab Invest
September 2023
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Article Synopsis
- Myocardial injury after non-cardiac surgery (MINS) can make patients more likely to have heart problems or even die after surgery.
- A study looked at patients who had hip fracture surgery to see if their blood clotting processes were different if they developed MINS.
- Out of 72 patients, 26 developed MINS, and those patients had notably higher levels of a blood marker called D-dimer, but other blood tests didn't show significant differences.
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