A new ophthalmic admission document has been devised which integrates existing medical and nursing input promoting a more consistent and concise assessment of the patient.
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Physiological Roles of Eumelanin- and Melanogenesis-Associated Diseases: A Look at the Potentialities of Engineered and Microbial Eumelanin in Clinical Practice.
Bioengineering (Basel)
July 2024
Dip.to di Scienze e Tecnologie Chimiche, Università degli Studi di Roma "Tor Vergata", 00133 Roma, Italy.
This paper aims to highlight the physiological actions exerted by eumelanin present in several organs/tissues of the human body and to rationalise the often conflicting functional roles played by this biopolymer on the basis of its peculiar properties. Besides pigmentary disorders, a growing number of organ injuries and degenerative pathologies are presently ascribed to the modification of physiological eumelanin levels in terms of alterations in its chemical/structural features, and of a partial loss or uneven distribution of the pigment. The present review analyses the more recent research dedicated to the physiological and pathological actions of eumelanin and provides an insight into some melanogenesis-associated diseases of the skin, eye, ear, and brain, including the most significant neurodegenerative disorders.
View Article and Find Full Text PDFIncidence of post vitrectomy endophthalmitis in India - A multicentric study by VRSI study Group.
Eye (Lond)
October 2023
Pink city eye and retina center, Jaipur, Rajasthan, India.
Introduction: The incidence of post vitrectomy endophthalmitis (PVE) is reported to be between 0.02 and 0.84%.
View Article and Find Full Text PDFImproving the provision of cataract surgery in New Zealand demands disruptive change.
N Z Med J
April 2022
Ophthalmologist, Department of Ophthalmology, Tairāwhiti District Health Board, Gisborne.
Cataract surgery is a highly cost-effective treatment, but the surgical intervention rate in New Zealand ranks poorly compared with other high-income countries. The combination of a growing and ageing population, lost operating time due to the COVID-19 pandemic, and geographical disparities, is driving up an unmet demand for cataract surgery. We present several evidence-based strategies with overlapping benefits in access, equity, efficiency and sustainability.
View Article and Find Full Text PDFRationalisation of Antifungal Properties of α-Helical Pore-Forming Peptide, Mastoparan B.
Molecules
February 2022
Ocular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.
The high mortality associated with invasive fungal infections, narrow spectrum of available antifungals, and increasing evolution of antifungal resistance necessitate the development of alternative therapies. Host defense peptides are regarded as the first line of defense against microbial invasion in both vertebrates and invertebrates. In this work, we investigated the effectiveness of four naturally occurring pore-forming antimicrobial peptides (melittin, magainin 2, cecropin A, and mastoparan B) against a panel of clinically relevant pathogens, including , , , and .
View Article and Find Full Text PDFCare and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study.
BMJ Open
December 2019
Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Introduction: Skin and soft tissue infections of the eye can be classified based on anatomic location as either anterior to the orbital septum (ie, periorbital cellulitis) or posterior to the orbital septum (ie, orbital cellulitis). These two conditions are often considered together in hospitalised children as clinical differentiation is difficult, especially in young children. Prior studies have identified variation in management of hospitalised children with orbital cellulitis; however, they have been limited either as single centre studies or by the use of administrative data which lacks clinical details important for interpreting variation in care.
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