To quantify the content of the signal-averaged electrocardiogram (ECG) in normal subjects, 100-beat signal-averaged Frank lead ECGs at a sampling rate of 1,000 Hz and with 16-bit resolution were recorded from 88 women and 102 men with a combined average age of 22 years. The QRS portion of each lead was digitally filtered in four bandwidths: 0-10, 10-60, 60-150, and 150-250 Hz. The root-mean-square voltage of each filtered signal was calculated as an absolute value and normalized as a percentage of the sum of the four filters. Women had significantly lower root-mean-square values in all filtered bands in Frank leads X and Z (P < .01). Normalized data, however, showed no sex difference (P > .05). Sex differences may affect quantitative measurement of the frequency content of the signal-averaged ECG.
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