Effects of disruption or stabilization of microfilaments or microtubules on formation of neuronal plastic reactions (NPR) were studied in isolated Lymnaea stagnalis neurons. Disruption of these cytoskeletal elements blocked the development of the NPR. After stabilization of the microtubules the dynamics of development and retention of the NPR became dependent on the stimulation series. Stabilization of the microfilaments blocked the development but improved the retention of the NPR. The role of the dynamic cytoskeletal reorganization in the process of NPR formation is discussed on the basis of the obtained data.
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