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An Innovative Use of Maxillofacial Implants for the Open Reduction and Internal Fixation of a Displaced Sternal Fracture: A Case Report.
Cureus
December 2024
Oral and Maxillofacial Surgery, Nagoya Tokushukai General Hospital, Kasugai, JPN.
Sternal fractures resulting from blunt chest trauma often present unique surgical challenges. While conservative management is common, cases with significant displacement, delayed union, or painful dyspnea may require surgical intervention to improve structural stability and relieve symptoms. Here, we report the case of a 46-year-old man who sustained a displaced sternal fracture in a motor vehicle accident.
View Article and Find Full Text PDFHybrid additive manufacturing for Zn-Mg casting for biomedical application.
In Vitro Model
December 2024
Department of Industrial and Manufacturing Engineering, Pennsylvania State University, State College, University Park, PA USA.
Zinc (Zn) and its alloys have been the focus of recent materials and manufacturing research for orthopaedic implants due to their favorable characteristics including desirable mechanical strength, biodegradability, and biocompatibility. In this research, a novel process involving additive manufacturing (AM) augmented casting was employed to fabricate zinc-magnesium (Zn-0.8 Mg) artifacts with surface lattices composed of triply periodic minimal surfaces (TPMS), specifically gyroid.
View Article and Find Full Text PDFMillimeter-scale radioluminescent power for electronic sensors.
iScience
January 2025
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA.
The storage and generation of electrical energy at the mm-scale is a core roadblock to realizing many untethered miniature systems, including industrial, environmental, and medically implanted sensors. We describe the potential to address the sensor energy requirement in a two-step process by first converting alpha radiation into light, which can then be translated into electrical power through a photovoltaic harvester circuit protected by a clear sealant. Different phosphorescent and scintillating materials were mixed with the alpha-emitter Th-227, and the conversion efficiency of europium-doped yttrium oxide was the highest at around 2%.
View Article and Find Full Text PDFA novel application perspective of the clinical-used drug verapamil on osteoporosis via targeting .
J Orthop Translat
January 2025
Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.
Background: RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification and therapeutic strategies development are important for the treatment of osteoporosis. The therapeutic effect of verapamil, a drug previously used for cardiovascular diseases, on diabetes was due to the inhibition of TXNIP expression, which has also been reported as a target in mice osteoporosis. Whether verapamil-inhibited TXNIP expression is related to osteoporosis and how it works on the molecular level is worthy to be explored.
View Article and Find Full Text PDFPyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury.
Nanoscale Adv
January 2025
Energy Materials Laboratory, Physics Department, School of Sciences and Engineering, The American University in Cairo New Cairo 11835 Egypt
Oxidative stress plays a major role in the secondary injury of the spinal cord tissue due to the high lipid content of nervous tissue. In the present study, coaxial nanofibers were loaded with the natural antioxidant pyrroloquinoline quinone (PQQ) and used as an implantable drug-delivery system and a scaffold post-SCI. The obtained data show that the concentration of NO and the activity of inducible nitric oxide synthase (iNOS) were significantly ( < 0.
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