Des-Arg9-bradykinin (des-Arg9-BK) caused endothelium-dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des-Arg9-BK were inhibited by the B1 receptor antagonist, des-Arg9-[Leu3]-BK (pK(B), 6.14 +/- 0.11) but were unaffected by the B2 receptor antagonist, Hoe-140. Therefore, this is the first demonstration that human coronary arteries possess endothelial B1 receptors which mediate endothelium-dependent relaxation and appear to be synthesized de novo during the incubation period.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1909186 | PMC |
| http://dx.doi.org/10.1111/j.1476-5381.1995.tb15108.x | DOI Listing |
Publication Analysis
Top Keywords
coronary arteries
12
endothelium-dependent relaxation
8
human coronary
8
receptor antagonist
8
relaxation kinin
4
kinin receptor
4
receptor agonist
4
agonist des-arg9-bradykinin
4
des-arg9-bradykinin human
4
arteries des-arg9-bradykinin
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!