Commentary on "Physiologically based pharmacokinetic modeling as a tool for drug development".

J Pharmacokinet Biopharm

Division of Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA.

Published: April 1995

Download full-text PDF

Source
http://dx.doi.org/10.1007/BF02354274DOI Listing

Publication Analysis

Top Keywords

commentary "physiologically
4
"physiologically based
4
based pharmacokinetic
4
pharmacokinetic modeling
4
modeling tool
4
tool drug
4
drug development"
4
commentary
1
based
1
pharmacokinetic
1

Similar Publications

The Application of Olive-Derived Polyphenols on Exercise-Induced Inflammation: A Scoping Review.

Nutrients

January 2025

Cambridge Centre for Sport and Exercise Sciences (CCSES), Faculty of Science and Engineering, Anglia Ruskin University, Cambridge CB1 1PT, UK.

Background/objectives: There is current scientific interest pertaining to the therapeutic effects of olive-derived polyphenols (ODPs), in particular their associated anti-inflammatory properties, following the wealth of research surrounding the physiological impact of the Mediterranean Diet (MD). Despite this association, the majority of the current literature investigates ODPs in conjunction with metabolic diseases. There is limited research focusing on ODPs and acute inflammation following exercise, regardless of the knowledge surrounding the elevated inflammatory response during this time.

View Article and Find Full Text PDF

Recent studies have shown that lactate is a molecule that plays an indispensable role in various physiological cellular processes, such as energy metabolism and signal transductions related to immune and inflammatory processes. For these reasons, interest in its detection using biosensors for non-invasive analyses of sweat during sports activity and in clinical reasons assessments has increased. In this minireview, an in-depth study was carried out on biosensors that exploited using electrochemical methods and innovative nanomaterials for lactate detection in sweat.

View Article and Find Full Text PDF

The aim of this study was to explore the feasibility of using electrodermal activity (EDA) to detect changes in physiological arousal linked to perceptions of accommodations, focusing on universal design (UD) features. In environments like hotels, designers must consider wellness, social integration, and cultural appropriateness to effectively implement UD. Challenges exist with implementing and evaluating UD to accommodate diverse user needs due to conflicting definitions and application issues.

View Article and Find Full Text PDF

Commentary on "Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth".

Mol Cancer

January 2025

Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

VTRNA2-1 is a polymorphically imprinted locus. The proportion of individuals with a maternally imprinted VTRNA2-1 locus is consistently approximately 75% in populations of European origin, with the remaining circa 25% having a non-methylated VTRNA2-1 locus. Recently, VTRNA2-1 hypermethylation at birth was suggested to be a precursor of paediatric acute lymphoblastic leukaemia with biomarker potential.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!