Pefloxacin (Rhone-Poulenc, France) was used prophylactically and therapeutically in 8 and 21 surgical inpatients respectively. The majority of the Enterobacteriaceae isolates were susceptible to pefloxacin (91 to 100 per cent). The isolates of Acinetobacter spp. and Pseudomonas aeruginosa were less susceptible (77 and 33.3 per cent respectively). The isolates of Staphylococcus aureus and S. epidermidis were mainly susceptible to the drug. The high antimicrobial activity of pefloxacin used therapeutically well correlated with the favourable time course of the main disease. When pefloxacin was used prophylactically the results were positive in all the cases. The drug tolerance in the majority of the cases was good. Only 2 patients developed allergic reactions as multiple minipunctate rash. After discontinuation of the drug use and short-term course of the desensitization the clinical sings of the allergic reactions disappeared in 3 days.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Process Improvement Initiative to Reduce Average Length of Stay in a Community Hospital - A Preliminary Report.
J Maine Med Cent
January 2024
Department of Medicine, MaineHealth, Portland, Maine.
Introduction: Average length of stay (ALOS) has increased in many US hospitals in the post-COVID-19-pandemic world. We undertook a process improvement initiative to reduce the ALOS in our community hospital.
Methods: Three core tactics were developed with a goal of reducing our ALOS by 10%.
Trends in dengue virus positivity & serotyping in Rajasthan.
Indian J Med Res
November 2024
Department of Health Research, Indian Council of Medical Research, New Delhi, India.
Background & objectives Dengue virus causes frequent outbreaks and epidemics with high morbidity and mortality. It is important to monitor the trends of the dengue virus and its serotypes. We carried out the present work to study the prevalence of the dengue virus and its serotypes in clinically suspected cases of dengue in Rajasthan.
View Article and Find Full Text PDFDisseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients.
J Natl Cancer Cent
December 2024
Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Article Synopsis
- Small cell lung cancer (SCLC) is aggressive, with aneuploid circulating tumor cells (DTCs) and endothelial cells (DTECs) believed to drive metastasis, but their clinical significance is still unclear.
- A study used advanced techniques to analyze DTCs and DTECs from 30 SCLC patients, including genetic sequencing to identify mutations in specific cell subtypes.
- Findings showed higher levels of DTCs and DTECs compared to circulating tumor cells, with certain detections linked to poorer survival outcomes and lower effectiveness of treatment, emphasizing the importance of these cells in patient prognosis.
Examining the Relationship between Aptamer Complexity and Molecular Discrimination of a Low-Epitope Target.
ACS Cent Sci
December 2024
Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Raleigh, North Carolina 27695, United States.
Aptamers are oligonucleotide-based affinity reagents that are increasingly being used in various applications. Systematic evolution of ligands by exponential enrichment (SELEX) has been widely used to isolate aptamers for small-molecule targets, but it remains challenging to generate aptamers with high affinity and specificity for targets with few functional groups. To address this challenge, we have systematically evaluated strategies for optimizing the isolation of aptamers for (+)-methamphetamine, a target for which previously reported aptamers have weak or no binding affinity.
View Article and Find Full Text PDFGovernance of biomedical research in the United States has been characterized by ethical individualism, a mode of reasoning that treats the individual person as the center of moral concern and analysis. However, genomics research raises ethics issues that uniquely affect certain genetically related communities as collectives, not merely as aggregates of individuals. This is especially true of identifiable populations-including Indigenous Peoples-that are often minoritized, socially marginalized, or geographically isolated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!