We have shown earlier that naltrexone, a long acting opioid antagonist, inhibits the development and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors. We extended these studies to determine the independent effects of naltrexone when fed at 75 mg/kg diet during the initiation (I), promotion (P), or initiation plus promotion (I+P) phases of DMBA-induced rat mammary carcinogenesis. The percentage of rats with palpable tumors as well as the number of tumors per rat were determined during the 130 day experiment. When fed during the 1, P, or I+P phases, mammary tumor incidence was significantly inhibited by 27%, 60% and 45% respectively, as compared to the control group. Similarly, tumor multiplicity was significantly reduced by naltrexone treatment. Tumor multiplicity was reduced by 40%, 73%, and 70% when fed naltrexone during I, P, and I+P respectively, as compared to the controls. These results indicate that naltrexone acts on the I and P phases, with the effects being maximal when fed during the P and I+P phases.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Atomic-Level Tin Regulation for High-Performance Zinc-Air Batteries.
J Am Chem Soc
January 2025
Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
The trade-off between the performances of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) presents a challenge in designing high-performance aqueous rechargeable zinc-air batteries (a-r-ZABs) due to sluggish kinetics and differing reaction requirements. Accurate control of the atomic and electronic structures is crucial for the rational design of efficient bifunctional oxygen electrocatalysts. Herein, we designed a Sn-Co/RuO trimetallic oxide utilizing dual-active sites and tin (Sn) regulation strategy by dispersing Co (for ORR) and auxiliary Sn into the near-surface and surface of RuO (for OER) to enhance both ORR and OER performances.
View Article and Find Full Text PDFPlastic responses to past environments shape adaptation to novel selection pressures.
Proc Natl Acad Sci U S A
February 2025
Molecular Ecology and Evolution Group, School of Environmental and Natural Sciences, Bangor University, Bangor LL57 2UW, United Kingdom.
Phenotypic plasticity may pave the way for rapid adaptation to newly encountered environments. Although it is often contested, there is growing evidence that initial plastic responses of ancestral populations to new environmental cues may promote subsequent adaptation. However, we do not know whether plasticity to cues present in the ancestral habitat (past-cue plasticity) can facilitate adaptation to novel cues.
View Article and Find Full Text PDFDeveloping and validating a HEalthCare NAvigation Competency (HECNAC) Scale for refugees in the United States.
PLoS One
January 2025
Health Promotion Sciences Department, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America.
The complex healthcare system in the United States (US) poses significant challenges for people, particularly minorities such as refugees. Refugees often encounter additional layers of challenges to healthcare navigation due to unfamiliarity with the system, limited health literacy, and language barriers. Despite their challenges, it is difficult to identify the gaps as few tools exist to measure navigation competency among this population and many conventional tools assume English proficiency, making them inadequate for refugees and other immigrants.
View Article and Find Full Text PDFGuards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity.
PLoS Pathog
January 2025
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Virulent microbes produce proteins that interact with host cell targets to promote pathogenesis. For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. To detect and respond to the activities of effectors, diverse phyla of host organisms evolved effector-triggered immunity (ETI).
View Article and Find Full Text PDFSynaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.
Elife
January 2025
Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Dopamine can play opposing physiological roles depending on the receptor subtype. In the fruit fly , and encode the D- and D-like receptors, respectively, and are reported to oppositely regulate intracellular cAMP levels. Here, we profiled the expression and subcellular localization of endogenous Dop1R1 and Dop2R in specific cell types in the mushroom body circuit.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!