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Thalamic deep brain stimulation for central poststroke pain syndrome: an international multicenter study.
J Neurosurg
January 2025
1Department of Neurosurgery, Inselspital, Bern University Hospital, University Bern, Switzerland.
Objective: The effectiveness and optimal stimulation site of deep brain stimulation (DBS) for central poststroke pain (CPSP) remain elusive. The objective of this retrospective international multicenter study was to assess clinical as well as neuroimaging-based predictors of long-term outcomes after DBS for CPSP.
Methods: The authors analyzed patient-based clinical and neuroimaging data of previously published and unpublished cohorts from 6 international DBS centers.
At First Sight: Fetal Eye Movements Reveal a Preference for Face-Like Configurations From 26 Weeks of Gestation.
Dev Sci
March 2025
Manibus Lab, Department of Psychology, University of Turin, Turin, Italy.
Previous research indicates that both adults and newborns show enhanced electrophysiological and behavioral responses to schematic face-like configurations (FCs-three dots composing a downward-pointing triangle), as compared to the inverted configurations (ICs). Even fetuses, when exposed to light stimuli projected through the uterine wall, preferentially orient their heads toward FCs rather than ICs. However, when this effect emerges along the third trimester of pregnancy and in relation to the maturation of which brain structures is still unknown.
View Article and Find Full Text PDFThalamo-insular cortex connections in the rat and human.
Neurosci Lett
December 2024
Department of Anatomy, Koç University, School of Medicine, Istanbul, Turkey. Electronic address:
The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans.
View Article and Find Full Text PDFOn brain stimulation in epilepsy.
Brain
January 2025
Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA.
Brain stimulation has, for many decades, been considered as a potential solution for the unmet needs of the many people living with drug-resistant epilepsy. Clinically, there are several different approaches in use, including vagus nerve stimulation (VNS), deep brain stimulation of the thalamus, and responsive neurostimulation (RNS). Across populations of patients, all deliver reductions in seizure load and SUDEP risk, yet do so variably, and the improvements seem incremental rather than transformative.
View Article and Find Full Text PDFA Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice.
Brain Behav
January 2025
Department of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China.
Article Synopsis
- Inflammation-related pain alters pain sensitivity in mice, evidenced by reduced paw withdrawal thresholds and latencies in CFA-induced pain models.
- Research highlights elevated c-Fos protein expression in the paraventricular nucleus of the thalamus (PVT), indicating neuron activation due to pain stimuli.
- The study utilized optogenetics to modulate the PVT-NAc neural circuit, showing its significant role in how inflammatory pain is experienced and managed.
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