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Article Synopsis
  • Borderline personality disorder (BPD) is linked to issues like emotional instability, impulsivity, and disrupted relationships, influenced by factors such as autonomic nervous system dysregulation and metabolic changes.
  • Research indicates that altered heart rate variability and HPA axis dysregulation, often due to early trauma, increase chronic inflammation and cardiovascular risk among individuals with BPD.
  • A review of 189 studies revealed key insights but had limitations, such as focusing on only one database and excluding non-English articles, suggesting a need for further research on this topic.
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Children today are immersed in electronic technology shortly after birth as they now begin regularly watching television earlier than they did in the past. Many new programs geared towards infants contain lots of lights, color, and sounds, which may constitute a form of sensory overstimulation (SOS) that leads to cognitive and behavioral changes in children and adolescents. Here, we examined the impact of early life SOS exposure on later life behavioral and cognitive function in rodents by exposing developing male and female rats to excessive audiovisual stimulation from postnatal days (PND) 10-40 and assessing anxiety-like behavior, social motivation, compulsive behavior, and spatial learning/cognition from PND 50-60.

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Hypothalamic and Pituitary Physiology in Birds and Reptiles.

Vet Clin North Am Exot Anim Pract

January 2025

Animal Health Center, SeaWorld San Antonio, 10500 SeaWorld Drive, San Antonio, TX 78251, USA; Department of Veterinary and Clinical Sciences, Utah State University, College of Veterinary Medicine, 5605 Old Main Hill, Logan, UT 84322, USA.

Across all vertebrates, the anatomy of the hypothalamus and mechanisms underlying its development are highly conserved, whereas the pituitary is highly specialized structurally with considerable differences amongst classes. In birds and reptiles, the hypothalamus controls the pituitary gland through nerve impulses and the secretion of neurohormones, resulting in several hypothalamic-pituitary axes: the hypothalamic-pituitary-thyroid axis, the hypothalamic-pituitary-adrenal axis, and the hypothalamic-pituitary-gonadal axis. This article provides a foundational knowledge on the physiologic function of the hypothalamus and pituitary in birds and reptiles, and their effects on behavior, homeostasis, and disease.

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Background: Drug addiction, characterized by compulsive drug use and high relapse rates, arises from complex interactions between reward and aversion systems in the brain. The paraventricular nucleus (PVN), located in the anterior hypothalamus, serves as a neuroendocrine center and is a key component of the hypothalamic-pituitary-adrenal axis.

Objective: This review aimed to explore how the PVN impacts reward and aversion in drug addiction through stress responses and emotional regulation and to evaluate the potential of PVN as a therapeutic target for drug addiction.

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Objective: Despite substantial research indicating difficulties with emotion regulation across eating disorder presentations, emotion regulation has yet to be studied in adults with avoidant/restrictive food intake disorder (ARFID). We hypothesized that (1) those with ARFID would report greater overall emotion regulation difficulties than nonclinical participants, and (2) those with ARFID would not differ from those with other eating disorders on the level of emotion regulation difficulty.

Methods: One hundred and thirty-seven adults (age 18-30) from an outpatient clinic with ARFID (n = 27), with other primarily restrictive eating disorders (e.

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