Seventy-seven normal donors underwent leukapheresis for peripheral blood progenitor cell collection beginning on day 4 (n = 45) or day 5 (n = 32) of filgrastim mobilization (12 micrograms/kg/d). The two groups were comparable for age, weight, blood volumes processed during leukapheresis and target CD34+ cell dose to be collected. The day 5 schedule allowed a more consistent achievement of the target cell dose with one apheresis (P = 0.005) and resulted in the initial collection of a significantly larger number of CD34+ cells (P = 0.009). There was no statistically significant difference in the leukapheresis yield of lymphoid subsets and natural killer cells.

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1747.xDOI Listing

Publication Analysis

Top Keywords

filgrastim mobilization
8
lymphoid subsets
8
normal donors
8
cell dose
8
duration filgrastim
4
mobilization apheresis
4
apheresis yield
4
yield cd34+
4
cd34+ progenitor
4
progenitor cells
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!