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Immuno-inflammatory pathogenesis in ischemic heart disease: perception and knowledge for neutrophil recruitment.
Front Immunol
July 2024
Department of Cardiovascular, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Ischemic heart disease (IHD) can trigger responses from the innate immune system, provoke aseptic inflammatory processes, and result in the recruitment and accumulation of neutrophils. Excessive recruitment of neutrophils is a potential driver of persistent cardiac inflammation. Once recruited, neutrophils are capable of secreting a plethora of inflammatory and chemotactic agents that intensify the inflammatory cascade.
View Article and Find Full Text PDFcGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation.
Cell Commun Signal
January 2024
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Background: Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression and organ degeneration, but the mechanism and regulation of the crosstalk network remain unclear. Cellular stress disrupts mitochondrial homeostasis, facilitates the opening of mitochondrial permeability transition pore and the leakage of mitochondrial DNA to cell membrane, triggers inflammatory responses by activating cGAS-STING signaling, and subsequently induces inflammasomes activation and the onset of pyroptosis. Meanwhile, the inflammasome-associated protein caspase-1, Gasdermin D, the CARD domain of ASC and the potassium channel are involved in regulating cGAS-STING pathway.
View Article and Find Full Text PDFXinfeng capsule inhibits lncRNA NONHSAT227927.1/TRAF2 to alleviate NF-κB-p65-induced immuno-inflammation in ankylosing spondylitis.
J Ethnopharmacol
April 2024
The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230038, Anhui, China; Anhui Province Key Laboratory of Modern Chinese Medicine Department of Internal Medicine Application Foundation Research and Development, Hefei, 230038, Anhui, China. Electronic address:
Ethnopharmacological Relevance: Ankylosing spondylitis (AS) is a chronic rheumatic disease known for its insidious and refractory symptoms, primarily associated with immuno-inflammation in its early stages, that affects the self-perception of patients (SPP). The exploration of long noncoding RNA (lncRNA) in immuno-inflammation of AS has garnered considerable interest. Additionally, the effectiveness of traditional Chinese medicine Xinfeng Capsule (XFC) in mitigating immuno-inflammation in AS has also been observed.
View Article and Find Full Text PDFA mitochondrial nexus in major depressive disorder: Integration with the psycho-immune-neuroendocrine network.
Biochim Biophys Acta Mol Basis Dis
February 2024
Hypoxia and Ischemia Research Unit, Griffith University, School of Health Sciences and Social Work, Australia. Electronic address:
Nervous system processes, including cognition and affective state, fundamentally rely on mitochondria. Impaired mitochondrial function is evident in major depressive disorder (MDD), reflecting cumulative detrimental influences of both extrinsic and intrinsic stressors, genetic predisposition, and mutation. Glucocorticoid 'stress' pathways converge on mitochondria; oxidative and nitrosative stresses in MDD are largely mitochondrial in origin; both initiate cascades promoting mitochondrial DNA (mtDNA) damage with disruptions to mitochondrial biogenesis and tryptophan catabolism.
View Article and Find Full Text PDFDouble-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy.
Cell Commun Signal
October 2023
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules. This pathway provides a delicate mechanism through which extracellular factors adjust gene expression, thereby acting as a substantial basis for environmental signals to influence cell growth and differentiation. The interactions between the JAK/STAT cascade and antiviral IFNs are critical to the host's immune response against viral microorganisms.
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