Objective: To determine the inflammatory potential of basic calcium phosphate (BCP) crystals, which have been identified in human joints.
Methods: Hydroxyapatite, carbonate apatite, whitlockite, and octacalcium phosphate crystals were injected in rat air pouches. Volume and cellularity of the exudate were measured. Physicochemical properties of the injected BCP crystals were determined, and correlations with the magnitude of induced inflammatory responses were sought.
Results: Significant differences were observed among the volumes and white blood cell (WBC) counts of the pouch exudates, based on the various crystal types used to induce inflammation. A strong correlation was demonstrated between the specific surface (SS) area of the injected crystals and the area under the curve for induced WBC count versus time (R2 = 0.88, P = 0.05). This correlation was observed for SS area values below 50 m2/gm, but when SS area increased further, this parameter plateaued. Another parameter of inflammatory response was obtained by dividing the area under the curve figuring WBC counts versus time by the corresponding SS area for each crystal type. This parameter increased linearly with the Ca:P ratio (R2 = 0.97, P = 0.0003).
Conclusion: The inflammatory potential of BCP crystals appeared to vary according to crystal features. SS area and the Ca:P ratio (which correlates with crystal solubility) influenced inflammatory properties. These results could explain the variable clinical consequences of BCP deposits, and must be taken into account in the choice of apatite ceramics for use as biomaterials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/art.1780390809 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Responsive Surfactant-Driven Morphology Transformation of Block Copolymer Microparticles.
Chemistry
January 2025
Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, State Key Laboratory of Materials Processing and Die & Mold Technology, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
Block copolymer (BCP) microparticles, which exhibit rapid change of morphology and physicochemical property in response to external stimuli, represent a promising avenue for the development of programmable smart materials. Among the methods available for generating BCP microparticles with adjustable morphologies, the confined assembly of BCPs within emulsions has emerged as a particularly facile and versatile approach. This review provides a comprehensive overview of the role of responsive surfactants in modulating interfacial interactions at the oil-water interface, which facilitates controlled BCP microparticle morphology.
View Article and Find Full Text PDFBimodal macroporous 3D scaffolds based on compatibilized PCL and PLA blend using PCL-PEG-PCL block copolymers and cellulose nanocrystals for osteogenic differentiation of hMSCs.
Int J Biol Macromol
January 2025
Pasteur Institute of Iran, Faculty of Bioscience and Biotechnology, Tehran, Iran.
In recent years, attempts were made to develop biomaterials using synthetic and natural polymers to induce osteogenesis of human mesenchymal stem cells (hMSCs). Poly(ε-caprolactone) (PCL) is one of the few synthetic polymers with the potential to differentiate hMSCs to bone. However, its potential is limited, attributed to its low strength; its fast crystallization rate also compromises its dimensional stability.
View Article and Find Full Text PDFNanoplatform for synergistic therapy constructed via the co-assembly of a reduction-responsive cholesterol-based block copolymer and a photothermal amphiphile.
Mater Today Bio
December 2024
Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
The goal of combination cancer therapy, including chemo-phototherapy, is to achieve highly efficient antitumor effects while minimizing the adverse reactions associated with conventional chemotherapy. Nevertheless, enhancing the contribution of non-chemotherapeutic strategies in combination therapy is often challenging because this requires multiple active ingredients to be encapsulated in a single delivery system. However, most commonly used photothermal reagents are challenging to be loaded in large quantities and have poor biocompatibility.
View Article and Find Full Text PDFControlled oligomerization of [1.1.1]propellane through radical polarity matching: selective synthesis of SF- and CFSF-containing [2]staffanes.
Beilstein J Org Chem
November 2024
Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, U.S.A.
Selectivity in radical chain oligomerizations involving [1.1.1]propellane - i.
View Article and Find Full Text PDFSoft optical materials based on the integration of perovskite nanostructures and block copolymers.
Chem Commun (Camb)
December 2024
School of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH 44325, USA.
Metal halide perovskites and their nanostructures have efficient optical absorption and emission in the visible range with high external quantum efficiency. They have been at the forefront of next-generation photovoltaics and optoelectronics applications. But several intrinsic limitations of perovskites including low stability and incompatibility with lithography-based patterning constrains their broader applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!