Serotonin induces platelet activation. Purified apoprotein E of 300 micrograms/ml prevented morphological alterations of blood platelets stimulated with serotonin (5 microM). Lower concentrated apoprotein E showed no such clear effects. These findings suggest that apoprotein E may liter atherosclerosis by suppressing agonist-induced platelet activation.
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| http://dx.doi.org/10.1002/(SICI)1096-8652(199608)52:4<319::AID-AJH14>3.0.CO;2-8 | DOI Listing |
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