Benchmarks are criteria and standards for resource expenditure, as well as other variables, derived from organizations or communities which have been identified as models of the most effective and efficient practices. The development of benchmarks is crucial to reducing lengths of stay and related costs in hospitals. Useful sources for benchmarking data and how to access them are summarized.
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Proc Natl Acad Sci U S A
February 2025
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, multistep chemical processes that are both time-consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure-activity relationships essential for effective mRNA delivery.
View Article and Find Full Text PDFPLoS One
January 2025
School of Industrial and Management Engineering, Korea University, Seongbuk-gu, Seoul, Republic of Korea.
A medical specialty prediction system for remote diagnosis can reduce the unexpected costs incurred by first-visit patients who visit the wrong hospital department for their symptoms. To develop medical specialty prediction systems, several researchers have explored clinical predictive models using real medical text data. Medical text data include large amounts of information regarding patients, which increases the sequence length.
View Article and Find Full Text PDFIntensive Crit Care Nurs
January 2025
Department of Environmental Engineering, Yildiz Technical University, İstanbul, Turkey.
Background: Surgical site infections (SSIs) are the most common postoperative complications after cesarean section (CS), with increased mortality, prolonged hospital stays, and increased healthcare costs.
Objective: To systematically estimate the global incidence and identify the risk factors associated with SSI, focusing on the variation between high- and low-income countries.
Search Strategy And Selection Criteria: Observational studies reporting on the incidence of SSI after CS were systematically searched in PubMed, Embase and SCOPUS.
Scand J Trauma Resusc Emerg Med
January 2025
Department of Emergency Medicine, Lausanne University Hospital and University of Lausanne, 21 Rue du Bugnon, BH 09, 1011, Lausanne, Switzerland.
Background: The Abbreviated Injury Scale (AIS) and Injury Severity Score (ISS) grade the severity of injuries and are useful for trauma audit and benchmarking. However, AIS coding is complex and requires specifically trained staff. A simple yet reliable scoring system is needed.
View Article and Find Full Text PDFJ Neuroeng Rehabil
January 2025
Luzerner Kantonsspital, University, Teaching and Research Hospital, University of Lucerne, Lucerne, Switzerland.
Background: Construct validity and responsiveness of upper limb outcome measures are essential to interpret motor recovery poststroke. Evaluating the associations between clinical upper limb measures and sensor-based arm use (AU) fosters a coherent understanding of motor recovery. Defining sensor-based AU metrics for intentional upper limb movements could be crucial in mitigating bias from walking-related activities.
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