Maximum likelihood methods are presented to test for the relations between causes and effects in linear path diagrams, without assuming that estimates of causes are free of error. Causal analysis is illustrated by published data of the Equal Educational Opportunity Survey, which show that American schools do not significantly modify socioeconomic differences in academic performance and that little of the observed racial difference in academic performance is causal. For two races differing by 15 IQ points, the differential if social class were randomized would be only about 3 points. The principle is stressed that a racial effect in a causal system may be environmental and that its etiology can be studied only by analysis of family resemblance in hybrid populations.
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http://dx.doi.org/10.1007/BF01066003 | DOI Listing |
J Youth Adolesc
December 2024
School of Psychology, Shanghai Normal University, Shanghai, China.
Few studies have comprehensively examined the reciprocal relation between specific parenting practices and children's academic performance across parent and child gender. The present study investigated the bidirectional associations between parental warmth/control and children's academic performance using a three-wave longitudinal multi-informant design. A total of 814 families (M = 10.
View Article and Find Full Text PDFCell Mol Biol Lett
December 2024
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Add: No.324, Jingwu Road, Jinan, 250021, Shandong, China.
Background: Disorders of lipid metabolism are critical factors in the progression of chronic lymphocytic leukemia (CLL). However, the characteristics of lipid metabolism and related regulatory mechanisms of CLL remain unclear.
Methods: Hence, we identified altered metabolites and aberrant lipid metabolism pathways in patients with CLL by ultra-high-performance liquid chromatography-mass spectrometry-based non-targeted lipidomics.
Sci Rep
December 2024
Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK.
Calcinosis cutis affects 20-40% of patients with systemic sclerosis. This study tests the hypothesis that calcium-chelating polycarboxylic acids can induce calcium dissolution without skin toxicity or irritancy. We compared citric acid (CA) and ethylenediaminetetraacetic acid (EDTA) to sodium thiosulfate (STS) for their ability to chelate calcium in vitro using a pharmaceutical dissolution model of calcinosis (hydroxyapatite (HAp) tablet), prior to evaluation of toxicity and irritancy in 2D in vitro skin models.
View Article and Find Full Text PDFEur J Cancer
December 2024
Department of Medicine, Institut Bergonié, Bordeaux, France. Electronic address:
Purpose: Molecular profiling is increasingly implemented to guide treatment of advanced pancreatic ductal adenocarcinoma (PDAC), especially when for clinical trials enrollment. This study aimed to describe actionable alterations detected in KRAS mutated (KRASm) versus KRAS wild-type (KRASwt) PDAC, the latter group being considered enriched in molecular alterations.
Methods: This prospective monocentric study included patients with locally advanced or metastatic PDAC who underwent next-generation sequencing (NGS) on liquid biopsy and/or tissue samples between 2015 and 2023, as part of the BIP academic study (NCT02534649).
Oral Radiol
December 2024
Department of Oral, Dental and Maxillofacial Radiology, Faculty of Dentistry, Ataturk University, Erzurum, 25240, Turkey.
Objective: The aim of this study is to determine the contact relationship and position of impacted mandibular third molar teeth (IMM) with the mandibular canal (MC) in panoramic radiography (PR) images using deep learning (DL) models trained with the help of cone beam computed tomography (CBCT) and DL to compare the performances of the architectures.
Methods: In this study, a total of 546 IMMs from 290 patients with CBCT and PR images were included. The performances of SqueezeNet, GoogLeNet, and Inception-v3 architectures in solving four problems on two different regions of interest (RoI) were evaluated.
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