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Auxiliary Liver Transplantation for Cirrhosis: From APOLT to RAPID: A Scoping Review.

Ann Surg

March 2022

Department of Digestive, Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière Hospital, Paris, France.

Article Synopsis
  • The study reviews literature on auxiliary liver transplantation (ALT) for cirrhosis, highlighting its innovative two-stage approach called RAPID.
  • ALT involves surgically removing parts of a cirrhotic liver and transplanting a liver graft, allowing the native liver to function alongside it until the graft grows.
  • The results from 72 cirrhotic patients showed that this approach can lead to significant improvements in liver function and increase the likelihood of successful transplantation outcomes.
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Peculiarities of course of diabetes mellitus (DM) in animal, simulated using alloxan, were suggested. There was given comparative characteristic of efficacy of deportalization operation, transplantation of pancreatic cellular-tissue culture and transplantation of pancreatoduodenal complex in treatment of DM basing on results of biochemical, hormonal and histological investigations.

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Late follow-up result of the pancreatic blood flow deportalization using distal splenorenal anastomosis conduction in 16 patients with type-I diabetes mellitus was studied up. The diabetes mellitus course stabilization was promoted by performance of operation.

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Free xenotransplantation of cryopreserved Langerhans cells (67 cases) and deportalization of pancreatic blood supply (37 patients) was done in 104 patients with insulin-dependent diabetes mellitus with positive effect. There were 58 men and 46 women at the age of 16-62 years. In 15 cases the combination of these two methods has been used that made it possible to enforce the antidiabetic effect and stabilize the development of diabetic complications.

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