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Dynamic pharyngeal carriage of Neisseria species in healthy population.
Infect Genet Evol
November 2024
Hubei Key Laboratory of Edible Wild Plants Conservation & Utilization, Hubei Engineering Research Center of Characteristic Wild Vegetable Breeding and Comprehensive Utilization Technology, Hubei Normal University, Huangshi City, Hubei Province, PR China. Electronic address:
Considering the significant role of commensal Neisseria carried in the pharynx on the variation of N.meningitidis and the acquisition of its resistance genes, understanding the true Neisseria population colonizing the human pharynx is of great significance. In this study, we carried out a five-month continuous survey of oropharyngeal carriage in a certain healthy population to reveal the long-term carriage status of different Neisseria species.
View Article and Find Full Text PDFEmergence and evolution of mosaic and alleles in a core genogroup that was historically susceptible to extended spectrum cephalosporins.
Front Microbiol
October 2024
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Article Synopsis
- The emergence of the FC428 clone of Neisseria gonorrhoeae (Ng) has led to concerns about antimicrobial resistance, with ceftriaxone being the last remaining effective treatment option due to the development of high-level resistance associated with a newly identified allele.
- Analysis of 2,104 genomes showed that three isolates with high-level ceftriaxone resistance grouped in a lineage that includes strains primarily from North America and Southeast Asia, indicating significant global spread and interconnectedness of resistant strains.
- The study identifies potential recombination events that could contribute to the evolution of resistant strains, highlighting the complex nature of antimicrobial resistance and the need for ongoing surveillance and research.
Antimicrobial susceptibility of commensal Neisseria spp. in parents and their children in Belgium: a cross-sectional survey.
FEMS Microbiol Lett
January 2024
Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, 2000 Antwerp, Belgium.
Background: commensal Neisseria species are part of the oropharyngeal microbiome and play an important role in nitrate reduction and protecting against colonization by pathogenic bacteria. They do, however, also serve as a reservoir of antimicrobial resistance. Little is known about the prevalence of these species in the general population, how this varies by age and how antimicrobial susceptibility varies between species.
View Article and Find Full Text PDFCiprofloxacin Concentrations 100-Fold Lower than the MIC Can Select for Ciprofloxacin Resistance in : An In Vitro Study.
Antibiotics (Basel)
June 2024
Sexually Transmitted Infections Unit, Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
Article Synopsis
- * A concentration of 0.06 µg/mL of ciprofloxacin was identified as the minimum selection concentration (MSC) for inducing resistance, significantly lower than the typical minimum inhibitory concentration (0.006 µg/mL).
- * Findings suggest that low levels of fluoroquinolones in the environment, including food and water, could promote the development of ciprofloxacin resistance in harmful bacteria.
Alteration of gastric microbiota in Helicobacter pylori-infected individuals suffering from GERD, DU, and gastritis.
Indian J Pathol Microbiol
June 2024
Center for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
Background/aim: Helicobacter pylori (H. pylori) colonization affects the gastric microbiome, causing gastrointestinal (GI) diseases. Modern sequencing technology provides insights into GI microbe interaction with H.
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