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or Yellow Oleander (Apocynaceae) Poisoning with Myocardial Bridging: An Autopsy-Based Case Report.
Wilderness Environ Med
March 2025
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, India.
Autopsy surgeons routinely encounter cases involving alleged use of poison. Many of these cases are due to poisonous plant species that grow wildly in different regions of the world and are readily accessible to the general population. (syn.
View Article and Find Full Text PDFMechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages.
Integr Cancer Ther
March 2025
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can promote the polarization of M2 macrophages and thus promote tumor development.
View Article and Find Full Text PDFTissue Printing Hybridization Using Digoxigenin-Labeled DNA Probes for the Detection of Geminiviruses and Associated DNA Satellites.
Methods Mol Biol
March 2025
Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Consejo Superior de Investigaciones Científicas, Algarrobo-Costa, Málaga, Spain.
Nucleic acid hybridization is a fundamental technique in plant virus research, enabling precise detection of plant pathogens. Tissue printing hybridization exhibits high sensitivity and specificity in detecting viral genomes, providing particularly valuable for screening a large number of samples without the need for DNA purification. This method virtually eliminates contamination and false positives.
View Article and Find Full Text PDFBackground: The RORγt (nuclear receptor retinoid-related orphan receptor γt) has been identified as a master transcription factor critical for the differentiation of T helper 17 cells, the primary source of IL-17A (interleukin-17A). We previously demonstrated that IL-17A promotes neuroinflammation and sympathetic excitation, contributing to cardiac dysfunction in heart failure and angiotensin II (ANG II)-induced hypertension. The present study sought to determine whether inhibiting RORγt, thereby reducing IL-17A production, could attenuate microglial activation, neuroinflammation, and sympathetic excitation by preserving the integrity of the blood-brain barrier (BBB) in ANG II-induced hypertensive rats.
View Article and Find Full Text PDFBufadienolide Penetration Through the Skin Membrane and Antiaging Properties of spp. Juices in Dermal Applications.
Molecules
February 2025
Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Skin aging is accelerated by inflammation processes generated by oxidative stress and external factors such as UV radiation. Plants belonging to the genus that are rich sources of antioxidants could potentially strengthen the skin barrier if used as ingredients in cosmetic formulations. However, their use is limited due to the contents of bufadienolides, known cardiotoxins.
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