Purpose: To determine the relationship between dose, volume, and the incidence of hip stiffness in patients who received conformal neutron irradiation for prostate cancer.
Methods And Materials: A series of dose-searching studies using neutron irradiation for prostate cancer were performed to determine the optimal dose, fraction size, field size, technique, and proportions of photon and neutron dose. Neutron doses ranged from 9 to 20 Gy and photon doses ranged from 0 to 38 Gy. Data were analyzed by using a hip stiffness grading scale.
Results: Hip stiffness was recorded on follow-up examination in 30% of patients (40 out of 132) treated with fast neutrons or mixtures of fast neutron and photon radiation for prostate cancer. Hip stiffness was categorized as none (Grade 0, 92 patients), mild (Grade 1, 24 patients), moderate (Grade 2, 10 patients), or severe (Grade 3, 6 patients). The incidence of hip stiffness differed significantly by dose and volume in the five dose levels studied (p < 0.001).
Conclusions: By using a mixture of conformal neutron and photon irradiation and limiting the total neutron dose to less than 13 Gy, hip stiffness toxicity could be reduced to acceptable levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0360-3016(96)00136-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Achieving cup target as per spinopelvic assessment is associated with improved THA outcome: a prospective, multicentre study.
Hip Int
January 2025
Department of Orthopaedic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
Background: Different methods can help to optimise sagittal cup orientation in total hip arthroplasty (THA) based on individual spinopelvic characteristics. This study aimed to: (1) assess how often combined sagittal index (CSI) and hip-spine-classification targets were achieved post THA; (2) compare anteversion/inclination between cups in-/outside optimal CSI zone; and (3) determine association with outcome.
Methods: This is a multicentre, prospective, case-cohort study of 435 primary THA for osteoarthritis (53% females; age: 65 ± 12 years; follow-up: 2.
Anti-Osteoporosis Is Imperative in Prevention of Progress of Ankylosing Spondylitis.
Int J Gen Med
January 2025
Spine Surgery, Peking University People's Hospital, Beijing, People's Republic of China.
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disease that affects the spine and peripheral joints, often leading to kyphosis, joint stiffness, and even ankylosis. Sagittal parameters, such as total thoracic kyphosis (TTK), thoracic kyphosis (TK), major thoracic kyphosis (MTK), and thoracolumbar kyphosis (TLK), are crucial indices for evaluating spinal alignment in AS patients and can reflect disease progression. This study aims to explore the relationship between bone mineral density (BMD), sagittal parameters, and joint ankylosis in AS patients.
View Article and Find Full Text PDFAssessment of the hip-spine relationship in total hip arthroplasty for childhood hip disorders sequelae.
World J Orthop
January 2025
Department of Orthopaedic Surgery, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, Chongqing 400043, China.
In this article, we comment on the article by Oommen . Oommen provided a comprehensive overview of the management of hip centre restoration in total hip arthroplasty (THA) for childhood hip disorder sequelae. Given the developmental disparity in this population, specific preoperative planning is an essential prerequisite for the success of THA procedures.
View Article and Find Full Text PDFThe Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.
Calcif Tissue Int
January 2025
Department of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.
Bone mechanical function is determined by multiple factors, some of which are still being elucidated. Here, we present a multivariate analysis of the role of bone tissue composition in the proximal femur stiffness of cadaver bones (n = 12, age 44-93). Stiffness was assessed by testing under loading conditions simulating a sideways fall onto the hip.
View Article and Find Full Text PDFAcute Effects of Passive Stretching with and Without Vibration on Hip Range of Motion, Temperature, and Stiffness Parameters in Male Elite Athletes.
J Funct Morphol Kinesiol
January 2025
Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria.
: Increasing exercise intensity and performance output with superimposed vibration gains interest, especially in high-performance training. However, the additional benefit of vibration in passive stretching exercises and its mechanisms remain unclarified. : Passive stretching with (ST+V) and without (ST) vibration (20 Hz) was performed in male Olympic youth skiing athletes ( = 8, age: 17.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!