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Disrupting Na ion homeostasis and Na/K ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo.
Cancer Metab
May 2024
School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Article Synopsis
- Cancer cells need more energy (ATP) to grow and survive, which can change how they take in and balance sodium ions in their bodies.
- The researchers used special methods to measure sodium levels and how fast cancer cells convert sugar into energy, comparing cancer cells to normal cells to see the differences.
- They found that when they blocked a specific pump that controls sodium balance (Na/K-ATPase), the cancer cells had more sodium and produced less energy, showing that sodium levels affect their energy production.
Detection and quantification of Na,K-ATPase dimers in the plasma membrane of living cells by FRET-FCS.
Biochim Biophys Acta Gen Subj
July 2024
Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Box 1031, 171 21 Solna, Sweden; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Box 1031, 171 21 Solna, Sweden.
The sodium potassium pump, Na,K-ATPase (NKA), is an integral plasma membrane protein, expressed in all eukaryotic cells. It is responsible for maintaining the transmembrane Na gradient and is the major determinant of the membrane potential. Self-interaction and oligomerization of NKA in cell membranes has been proposed and discussed but is still an open question.
View Article and Find Full Text PDFHigh dietary lipid level promotes low salinity adaptation in the marine euryhaline crab ().
Anim Nutr
March 2023
Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China.
The physiological processes involved in adaptation to osmotic pressure in euryhaline crustaceans are highly energy demanding, but the effects of dietary lipids (fat) on low salinity adaptations have not been well evaluated. In the present study, a total of 120 mud crabs (, BW = 17.87 ± 1.
View Article and Find Full Text PDFAdvances in understanding the molecular structure of retinoschisin while questions remain of biological function.
Prog Retin Eye Res
July 2023
Center for Ocular Regenerative Therapy, Ophthalmology, U C Davis Health, Sacramento, CA, 95817, USA.
Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that leads to vision loss in young males. A key manifestation of XLRS is the formation of cavities (cysts) in the retina and separation of the layers (schisis), disrupting synaptic transmission.
View Article and Find Full Text PDFAn Introduction to Spiral Steroids.
Int J Mol Sci
August 2022
IOMA LLC, Belmont, CA 94002-3321, USA.
In addition to classical steroids, which have cholesterol as a precursor, there are steroids with 7-dehydrocholesterol as a precursor. This review describes the identification of these steroids, their biosynthesis, and some aspects of their function. There are three classes of these compounds, distinguished by the number of their carbon atoms, 23, 24, and 25.
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