The purpose of this paper is to look from a very general viewpoint to the interaction of factors which contribute to the process of aging. Life time is the most significant period for an individual. Several theories try to explain the process of aging by genetic determinants, by genetic or metabolic defects, by immunologic failure or by other reasons. It is noteworthy that the duration of life is correlated to the size of the body of different animals. This fact indicates a close relation to metabolism. It can be assumed that under optimal conditions of life, defects in function or structure are repaired by special maintenance functions. During the process of aging these functions lose effectuality.
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Environ Sci Technol
January 2025
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Selective catalytic reduction of NO by NH(NH-SCR) remains challenging for diesel vehicles due to the complex exhaust condition. Cu-SAPO-18 zeolite has emerged as an efficient catalyst for the NH-SCR process, attributed to its unique small pore configuration and high NH-SCR activity. Herein, Zr-modified Cu-SAPO-18 has been fabricated and evaluated for the reduction of NO.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
State Key Laboratory of Genetic Engineering, School of Life Sciences, Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Aging is a complex process that affects multiple organs, and the discovery of a pharmacological approach to ameliorate aging is considered the Holy Grail of medicine. Here, we performed an N-ethyl-N-nitrosourea forward genetic screening in zebrafish and identified an accelerated aging mutant named (), harboring a mutation in the - () gene. Loss of leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Physics, Chair for Functional Materials, TUM School of Natural Sciences, Technical University of Munich, James-Franck-Str. 1, 85748 Garching, Germany.
Solid additives have garnered significant attention due to their numerous advantages over liquid additives. This study explores the potential of the green-fluorescent conjugated polymer denoted Atums Green as a solid additive in green-solvent-based PBDB-TF-T1:BTP-4F-12 solar cells. Even tiny amounts of Atums Green doping significantly improve the device performance.
View Article and Find Full Text PDFJ Am Med Inform Assoc
January 2025
Institute of Intelligent Rehabilitation Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Background: With the global population aging and advancements in the medical system, long-term care in healthcare institutions and home settings has become essential for older adults with disabilities. However, the diverse and scattered care requirements of these individuals make developing effective long-term care plans heavily reliant on professional nursing staff, and even experienced caregivers may make mistakes or face confusion during the care plan development process. Consequently, there is a rigid demand for intelligent systems that can recommend comprehensive long-term care plans for older adults with disabilities who have stable clinical conditions.
View Article and Find Full Text PDFPulmonology
December 2025
Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK.
Age-related lung function decline is associated with small airway closure and gas trapping. The mechanisms which cause these changes are not fully understood. It has been suggested that COPD is caused by accelerated ageing.
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