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1-year efficacy results after MR-guided risk-adapted stereotactic radiotherapy of infra-diaphragmatic oligometastases in a multicenter phase II trial.
Radiother Oncol
January 2025
Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, Herlev 2730 Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark.
Background And Purpose: The SOFT (Stereotactic ablative radiotherapy of infra-diaphragmatic sOFT tissue metastases) trial assesses the safety and efficacy of risk-adapted MR-guided stereotactic ablative radiotherapy (SABR) of infra-diaphragmatic soft tissue metastasis in patients with oligometastatic disease (OMD) (clinicaltrials.gov ID NCT04407897). This paper reports the one-year efficacy analysis and evaluates associations between local control (LC) and clinical and dosimetric parameters.
View Article and Find Full Text PDFTHE IMPACT OF NEUTROPHIL-TO-LYMPHOCYTE RATIO ON SHORT- AND LONG-TERM PROGNOSIS FOLLOWING ELECTIVE INFRARENAL EVAR.
Ann Vasc Surg
January 2025
Hospital de Santa Marta, Unidade Local de Saúde São José, Lisboa, Portugal.
Objective: Neutrophil-to-lymphocyte ratio (NLR) is a readily available parameter, associated with long-term outcomes in cardiovascular conditions. This study aims to analyze the predictors of NLR and its impact on prognosis and disease-specific outcomes following EVAR.
Methods: Single-center retrospective cohort study.
Technical and clinical outcomes of 13 years of endovascular repair of infrarenal, atherosclerotic, penetrating aortic ulcers.
Ann Vasc Surg
January 2025
Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Objectives: To report the technical and clinical outcomes of endovascular repair of all infrarenal, penetrating aortic ulcers (PAU) that were treated at a single institution over a 13-year period.
Methods: This is a single-center, retrospective observational study. All patients consecutively treated for atherosclerotic, infrarenal PAU were included between 2010 and 2023.
Cost-effectiveness of robotic compared with laparoscopic rectal resection. Results from the Spanish prospective national trial ROBOCOSTES.
Surgery
January 2025
Hepato Pancreato Biliary Unit. Hospital del Mar. Pompeu Fabra University, Barcelona, Spain. Electronic address:
Objective: The costs related to robotic surgery are known to be greater than those associated with laparoscopy. However, the potential for better outcomes of the former could lead to a cost-effectiveness advantage. The aim of this study is therefore to highlight the difference in cost-effectiveness between robotic and laparoscopic rectal resection.
View Article and Find Full Text PDFManagement of presymptomatic juvenile patients with late-onset Pompe disease (LOPD).
Neuromuscul Disord
January 2025
ERN-NMD Center for Neuromuscular Disorders of Messina - Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address:
Late-onset Pompe disease (LOPD) includes patients from 1 year of age to adulthood. The vast heterogeneity in clinical manifestations and disease progression is not fully explained; however, a short disease duration and a young age seem to be good predictors of a better response to treatment. For this purpose, we investigated and followed up a cohort of 13 juvenile patients with LOPD from the clinical and therapeutic point of view, mainly pointing out the transition from presymptomatic to symptomatic status.
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