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Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.
PLoS Negl Trop Dis
January 2025
Center for Infection and Molecular Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality-deserving equal attention. Three potentially life-threatening endemic bacterial diseases (leptospirosis, melioidosis, and rickettsioses) are a huge public health concern especially in low- and middle-income countries.
View Article and Find Full Text PDFA novel ready-to-use loop-mediated isothermal amplification (LAMP) method for detection of Burkholderia mallei and B. pseudomallei.
BMC Microbiol
January 2025
Laboratory of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, Hokkaido, 060-0818, Japan.
Background: Glanders and melioidosis are contagious zoonotic diseases caused by Burkholderia mallei and B. pseudomallei, respectively. Bacterial isolation and polymerase chain reaction (PCR) have been used to detect these bacteria in animals suspected of infection; however, both methods require skilled experimental techniques and expensive equipment.
View Article and Find Full Text PDFPerformance of Antibody-Detection Tests for Human Melioidosis: A Systematic Review and Meta-analysis.
Malays J Med Sci
December 2024
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kelantan, Malaysia.
Melioidosis is a life-threatening infectious disease caused by the bacterium . Although culture is the gold standard for diagnosing melioidosis, it is time-consuming and delays timely treatment. Non-culture-based diagnostic techniques are interesting alternatives for the rapid detection of melioidosis.
View Article and Find Full Text PDFClinical and Microbiological Profile of Melioidosis in a Tertiary Care Hospital in Kerala, India.
Am J Trop Med Hyg
January 2025
Department of Microbiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India.
Melioidosis is a neglected tropical infection caused by the Gram-negative bacterium Burkholderia pseudomallei, which is found in soil and water across tropical countries. The infection spectrum ranges from mild localized lesions to severe sepsis. The clinical presentation, severity, and outcome are influenced by the route of infection, bacterial load, strain virulence, and specific virulence genes of B.
View Article and Find Full Text PDFIdentification of Environmental Determinants Involved in the Distribution of Burkholderia pseudomallei in Southeast Asia using MaxEnt software.
PLoS Negl Trop Dis
January 2025
Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, Philippines.
Burkholderia pseudomallei (Bp), causing melioidosis, is becoming a major global public health concern. It is highly endemic in Southeast Asia (SEA) and Northern Australia and is persisting beyond the established areas of endemicity. This study aimed to determine the environmental variables that would predict the most suitable ecological niche for this pathogenic bacterium in SEA by maximum entropy (MaxEnt) modeling.
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