Background: Degenerative changes in the lumbosacral portion of the spine are frequently associated with the lumboischiadic syndrome (LI syndrome). Its treatment is traditionally conservative or surgical. In the seventies and eighties to these two procedures percutaneous punctures were added. The objective of the authors is to present their own experience with a new puncture method of LI syndrome--APLD (automated percutaneous lumbar discectomy).
Methods And Results: The number of operated patients in 1991-1994 comprised 45 patients, 19 men and 28 women, mean age 40.7 years (18-64 years). APLD was performed 47 times (four times at the level of L3/4, 30 times at the level of L4/5 and 13 times at the level of L5/S1; in two subjects the operation was repeated because the first operation was not effective. APLD is a miniinvasive method made under local anaesthesia with skiascopic control, using special instruments of Surgical Dynamics, USA. Patients with the LI syndrome are selected for treatment according to strict clinical and radiological criteria, the effectiveness of treatment depends on the selection of patients. In the published group treatment was successful in 83% (17% not improved, 38% improved, 45% cured) which is consistent with the experience of others, in particular authors abroad. Only in one instance a minor peroperative complication occurred; the authors did not record any postoperative complications.
Conclusions: APLD is an effective and safe method of invasive treatment of prolapse of lumbar intervertebral discs in an indicated group of patients. It does not replace surgical treatment but reduces the period of conservative treatment. If this treatment is not successful after 4-6 weeks, APLD should be the method of choice. Therefore doctors who are the first to treat these patients should become familiar with the clinical indications.
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J Cachexia Sarcopenia Muscle
February 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Background: With a decline of 17β-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that genes and pathways related to contraction and maintenance of mass are differentially expressed in ovariectomized mice with and without E2 treatment.
Methods: Soleus and tibialis anterior (TA) muscles from C57BL/6 ovariectomized mice treated with placebo (OVX) or E2 (OVX + E2) for 60 days, or from skeletal muscle-specific ERα knockout (skmERαKO) mice and wild-type littermates (skmERαWT), were used for genome-wide expression profiling, quantitative real-time PCR and immunoblotting.
Protein Sci
February 2025
Cell Physiology and Molecular Biophysics Department, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Purifying membrane proteins has been the limiting step for studying their structure and function. The challenges of the process include the low expression levels in heterologous systems and the requirement for their biochemical stabilization in solution. The human voltage-gated proton channel (hH1) is a good example of that: the published protocols to express and purify hH1 produce low protein quantities at high costs, which is an issue for systematically characterizing its structure and function.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Orthopedic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, Xuzhou, Jiangsu, 221002, China.
Purpose: To compare the efficacy and safety of skip titanium plates combined with adjacent spinous process suture suspension versus continuous titanium plate fixation in cervical laminoplasty.
Methods: A retrospective analysis of 125 patients (62 men, 63 women, average age 60.9 ± 10.
Contracept Reprod Med
January 2025
Department of Public Health Nursing, School of Nursing and Midwifery, University of Health and Allied Sciences, PMB 31, Ho, Volta Region, Ghana.
Background: Male knowledge and acceptance of modern contraceptive use play a significant role in uptake. This study assessed the factors associated with male acceptance of modern contraceptive methods in Ho Municipality.
Methods: A cross-sectional study with a quantitative approach was employed.
Ital J Pediatr
January 2025
Department of developmental and behavior pediatrics, Children's Medical Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Background: Recent studies have emphasized the association between prolonged screen exposure and neurodevelopmental disorders, though its correlation with tic disorders (TDs) remains ambiguous. We thus conducted this study to investigate the association between screen time (ST) and the severity of tic symptoms in children diagnosed with TDs.
Methods: We conducted a retrospective case-control study with 342 cases of TDs and 270 controls, collecting data from March 2021 to December 2023.
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