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Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease.
Arch Pharm (Weinheim)
January 2025
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.
New conjugates of amiridine and salicylic derivatives (salicylamide, salicylimine, and salicylamine) with different lengths of alkylene spacers were designed, synthesized, and evaluated as potential multifunctional central nervous system therapeutic agents for Alzheimer's disease (AD). Conjugates demonstrated high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition (IC: AChE, 0.265-4.
View Article and Find Full Text PDF[Efficiency evaluation of the Neuromidin in the treatment of pain of the patients with discogenic lumbosacral radiculopathy: results of a multicenter post-registration prospective open comparative trial].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2024
Medical center «Admiralteyskie verfi», St. Petersburg, Russia.
Article Synopsis
- - The study aimed to assess the impact of Neuromidine on pain relief for patients suffering from discogenic lumbosacral radiculopathy, comparing a treatment group (OG) that received Neuromidine alongside standard therapy to a control group (HS) that only received standard therapy.
- - After 8 weeks, the treatment group showed significantly greater reductions in pain intensity, improved cognitive function, and better emotional health compared to the control group, along with a marked decrease in the inflammatory marker IL-6.
- - Neuromidine was well-tolerated with no reported side effects, indicating its potential effectiveness and safety as an addition to existing treatment modalities for this condition.
Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β-amyloid aggregation.
Arch Pharm (Weinheim)
February 2024
Postovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
New amiridine-thiouracil conjugates with different substituents in the pyrimidine fragment (R = CH , CF Н, CF , (CF ) H) and different spacer lengths (n = 1-3) were synthesized. The conjugates rather weakly inhibit acetylcholinesterase (AChE) and exhibit high inhibitory activity (IC up to 0.752 ± 0.
View Article and Find Full Text PDFAim: To investigate the neurofunctional parameters in breast cancer (BC) patients with paclitaxel-induced peripheral neuropathy (PIPN) and to clarify the feasibility of using alpha-lipoic acid (ALA) in combination with the acetylcholinesterase inhibitor ipidacrine hydrochloride (IPD) for its prevention.
Materials And Methods: 100 BC patients (T1-4N0-3M0-1) prescribed for polychemotherapy (PCT) by the AT (paclitaxel, doxorubicin) or ET (paclitaxel, epirubicin) regimens in the neoadjuvant, adjuvant or palliative modes, were enrolled. The patients were randomized into two groups (n = 50 per group): group I treated by PCT only; group II treated with PCT plus the studied PIPN prevention scheme (ALA in combination with IPD).
Aim: To evaluate the efficacy of combination of alpha-lipoic acid and acetylcholinesterase inhibitor (ipidacrine hydrochloride) to prevent the development and improve the course of paclitaxel-induced peripheral neuropathy (PIPN) in patients with breast cancer according to the Total Neuropathy Score.
Materials And Methods: 32 patients with breast cancer T1-4N0-3M0 received six cycles of polychemotherapy according to the AT scheme (paclitaxel, doxorubicin) or ET scheme (paclitaxel, epirubicin). Patients were randomized into two groups - without (group I) or with (group II) medication for prevention of neuropathy.
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