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Postepy Biochem
December 2024
Department of Molecular Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw.
Mikrobiota układu pokarmowego jest nieodzownym elementem właściwego funkcjonowania organizmu człowieka, bowiem drobnoustroje jelitowe i ich metabolity silnie wpływają na metabolizm gospodarza i funkcje odpornościowe, jak również przyczyniają się do biosyntezy witamin, produkcji hormonów jelitowych, utrzymania integralności bariery jelitowej i ochrony przed patogenami, a także trawienia i wchłaniania składników odżywczych. Coraz częściej podkreśla się istnienie zależności pomiędzy zaburzeniami składu mikrobioty jelit a pojawianiem się chorób metabolicznych, tj. otyłości czy cukrzycy typu 2.
View Article and Find Full Text PDFCirculating MicroRNAs Related to Arterial Stiffness in Adults with HIV Infection.
Viruses
December 2024
1st Internal Medicine Department, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, 55436 Thessaloniki, Greece.
People with HIV (PWH) have an elevated risk of cardiovascular disease compared to those without HIV. This study aimed to investigate the relative serum expression of microRNAs (miRNAs) associated with arterial stiffness, a significant marker of cardiovascular disease. A total of 36 male PWH and 36 people without HIV, matched for age, body mass index, pack years, and dyslipidemia, were included in the study.
View Article and Find Full Text PDFChronic Hepatitis C Infection Treated with Direct-Acting Antiviral Agents and Occurrence/Recurrence of Hepatocellular Carcinoma: Does It Still Matter?
Viruses
December 2024
Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.
Hepatitis C virus (HCV) infection is a significant risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). Traditionally, the primary prevention strategy for HCV-associated HCC has focused on removing infection through antiviral regimes. Currently, highly effective direct-acting antivirals (DAAs) offer extraordinary success across all patient categories, including cirrhotics.
View Article and Find Full Text PDFThe Laboratory Opossum () Is a Unique Model for Research on Zika Virus: Robust Immune Response, Widespread Dissemination, and Long-Term Persistence.
Viruses
November 2024
Division of Human Genetics, School of Medicine, The University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, McAllen, TX 78520, USA.
The Zika virus (ZIKV) epidemic elicited a rapid commitment to the development of animal models for ZIKV research. Non-human primates (NHPs) and mice have made significant contributions to this research, but NHPs are expensive, have a long gestation period, and are available only in small numbers; non-genetically modified mice are resistant to infection. To address these deficiencies, we have established the laboratory opossum, , as a small animal model that complements the mouse and monkey models.
View Article and Find Full Text PDFRegulates the Immune Response and Gut Microbiota in Mice.
Nutrients
December 2024
Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki 701-0193, Japan.
Background: Cactus contains dietary fiber and minerals and is expected to have preventive effects against diabetes, arteriosclerosis, and other diseases. Additionally, cactus intake induces the production of short-chain fatty acids derived from the gut microbiota, which might influence immune functions. In this study, we examined the effects of a cactus (: NC)-supplemented diet on lipopolysaccharide (LPS)-induced immune responses and intestinal barrier function.
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